Effect of Nutritional Interventions on Serum C-reactive Protein Levels in Patients with Periodontitis: A Comprehensive Meta-Analysis

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2024-01-14 DOI:10.37290/ctnr2641-452x.22:412-418

Liu Jian, Yang Yi, Chen Shan, Taohua Pan

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Abstract

Elevated level of serum C-reactive protein, a systemic inflammation biomarker, is associated with periodontitis, a common inflammatory condition. This meta-analysis aimed to determine the effects of nutritional interventions on serum C-reactive protein levels in patients with periodontitis. We searched the Cochrane Library, PubMed, Scopus, and Web of Science databases according to PRISMA guidelines, including articles published until December 2023. The articles were selected according to predetermined inclusion criteria, and data extraction and quality assessment were conducted utilizing the Newcastle-Ottawa Scale and standardized forms. Seven out of 438 identified articles met the inclusion criteria. We found that patients with periodontitis had a statistically significant correlation between nutritional interventions and decreased serum C-reactive protein levels (p < 0.05). The interventions included specified dietary modifications and dietary supplements, including vitamin C and folic acid. Diverse patient demographics and intervention categories were observed across the identified articles. Thus, this meta-analysis confirmed that nutritional interventions can reduce serum C-reactive protein levels in patients with periodontitis; therefore, dietary modification is essential in managing the systemic inflammation associated with periodontal disease.

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营养干预对牙周炎患者血清 C 反应蛋白水平的影响：综合元分析

血清 C 反应蛋白是一种全身性炎症生物标志物，它的升高与牙周炎这种常见的炎症有关。本荟萃分析旨在确定营养干预对牙周炎患者血清 C 反应蛋白水平的影响。我们根据 PRISMA 指南检索了 Cochrane 图书馆、PubMed、Scopus 和 Web of Science 数据库，包括 2023 年 12 月之前发表的文章。文章按照预先确定的纳入标准进行筛选，并使用纽卡斯尔-渥太华量表和标准化表格进行数据提取和质量评估。在确定的 438 篇文章中，有 7 篇符合纳入标准。我们发现，牙周炎患者的营养干预与血清 C 反应蛋白水平的降低之间存在统计学意义上的显著相关性（P < 0.05）。干预措施包括特定的饮食调整和膳食补充剂，包括维生素 C 和叶酸。在已确定的文章中观察到了不同的患者人口统计学特征和干预类别。因此，这项荟萃分析证实，营养干预措施可降低牙周炎患者的血清 C 反应蛋白水平；因此，调整饮食对控制与牙周疾病相关的全身炎症至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.

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