SIMPLE COST-EFFECTIVE STABILITY INDICATING METHOD FOR THE ESTIMATION OF AVANAFIL IN BULK OR FORMULATION BY RP-HPLC

Abstract

This research presents a comprehensive analytical approach for the estimation of avanafil, a phosphodiesterase type 5 (PDE5) inhibitor used in the treatment of erectile dysfunction. The developed method utilizes Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) and focuses on stability indication, linearity, precision, and robustness. System suitability parameters, linearity, recovery studies, and forced degradation studies were conducted to validate the method's efficacy. The results indicate a reliable and cost-effective approach for the estimation of avanafil in both bulk and pharmaceutical formulations. The method demonstrates sensitivity, precision, and stability-indicating characteristics, making it a valuable tool for routine quality control processes in the pharmaceutical industry.