EXPLORING OF SERUM PON 1 ACTIVITY AND ITS ASSOCIATION WITH HDL IN PRE AND POST DIALYSIS CRF PATIENTS : A COMPARATIVE STUDY

Abstract

Background Dyslipidemia is frequently have lipoprotein abnormalities such as low HDL-C concentrations, increased remnant particles and hypertriglyceridemia. HDL-C concentrations are inversely correlated with atherogenic risk. PON-1 activity was lower in patients with renal insufficiency Aim & Objectives 1) To evaluate activity of PON-1 activity in patients with CRF during pre- and post- hemodialysis sessions 2) To establish interrelationships if any,between PON-1,blood urea and serum creatinine levels. 3) To identify the association of PON -1 with serum HDL levels among CRF patients Materials And Methods Hospital based case-control study consists of 40 patients who were receiving Hemodialysis (HD) therapy in the dialysis unit. Study designed to evaluate alterations in serum PON -1 activity in patients during pre and post dialysis sessions in CRF. Result About 17% increase in the activities of PON-1 have been evident during posthemodialysis as compared to pre-hemodialysis samples of patients with CRF.The mean activity of PON-1 and HDL were decreased in pre-hemodialysis samples of patients with CRF. PON-1 activity and HDL was increased in CRF patients during post-hemodialysis as compared to pre-hemodialysis sessions. In both, the results were statistically highly significant (p < 0.001).There is a positive correaltion between HDL and PON 1. Conclusion This study demonstrates that there is an increased risk of cardiovascular complications in patients undergoing hemodialysis. CRF patients undergoing hemodialysis show an increased generation of reactive oxygen species accompanied by an altered lipid profile and paraoxonase-1.