FAST DISSOLVING ORAL FILM: A BOON FOR PATIENTS SUFFERING WITH NAUSEA AND VOMITING

Abstract

For patients receiving chemotherapy and radiation therapy, nausea and vomiting are serious issues. Moreover, post-operative nausea and vomiting are common side effects. Postoperative nausea and vomiting (PONV) is thought to occur in 25–30% of cases. Furthermore, oral thin films provide accurate and adaptable dosing. Oral films are made easier and more convenient by these qualities, which also have positive medicinal effects. Drugs are rapidly absorbed in the mouth when administered via buccal or sublingual film delivery. This reduces exposure to the gastrointestinal system and addresses issues that are frequently related to tablets and capsules, including first-pass metabolism, gastrointestinal adverse effects, and sluggish or restricted absorption in the GI tract. Consequently, buccal or sublingual films might provide increased patient compliance, decreased adverse effects, and higher absorption. This article provides a thorough understanding of emesis, including its causes, treatments for emesis, innovative oral thin-film drug delivery, its properties, methods for fabrication and assessment, and, finally, previously published research on antiemetic oral thin-film.