FAST DISSOLVING ORAL FILM: A BOON FOR PATIENTS SUFFERING WITH NAUSEA AND VOMITING

Sakshi Chandrakant Wankhede, Pankaj M. Pimpalshende, S. Kosalge
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Abstract

For patients receiving chemotherapy and radiation therapy, nausea and vomiting are serious issues. Moreover, post-operative nausea and vomiting are common side effects. Postoperative nausea and vomiting (PONV) is thought to occur in 25–30% of cases. Furthermore, oral thin films provide accurate and adaptable dosing. Oral films are made easier and more convenient by these qualities, which also have positive medicinal effects. Drugs are rapidly absorbed in the mouth when administered via buccal or sublingual film delivery. This reduces exposure to the gastrointestinal system and addresses issues that are frequently related to tablets and capsules, including first-pass metabolism, gastrointestinal adverse effects, and sluggish or restricted absorption in the GI tract. Consequently, buccal or sublingual films might provide increased patient compliance, decreased adverse effects, and higher absorption. This article provides a thorough understanding of emesis, including its causes, treatments for emesis, innovative oral thin-film drug delivery, its properties, methods for fabrication and assessment, and, finally, previously published research on antiemetic oral thin-film.
快速溶解口服膜:恶心呕吐患者的福音
对于接受化疗和放疗的患者来说,恶心和呕吐是很严重的问题。此外,术后恶心和呕吐也是常见的副作用。术后恶心和呕吐(PONV)的发生率为 25%-30%。此外,口服薄膜可提供准确且适应性强的剂量。口服薄膜的这些特性使其更加简单方便,同时也具有积极的药用效果。通过口腔或舌下薄膜给药时,药物在口腔中吸收迅速。这减少了药物暴露于胃肠道系统的机会,解决了药片和胶囊经常出现的问题,包括首过代谢、胃肠道不良反应、胃肠道吸收迟缓或受限。因此,颊膜或舌下膜可提高患者的依从性、减少不良反应并促进吸收。本文全面介绍了止吐,包括其原因、止吐治疗方法、创新口服薄膜给药、其特性、制作和评估方法,最后还介绍了以前发表的有关止吐口服薄膜的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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