Effect of mangiferin and giloy herbal extract: Future home remedy for glycemic control by insulin secretion in type 2 diabetes mellitus

Abstract

Introduction: Diabetes mellitus is a metabolic disorder that has a number of allopathic treatments in practice which are having adverse side effects. Mangiferin and giloy are the important Ayurvedic medications. Both have effective control over diabetes glycemic status. It is possible that the treatment of certain herbal remedies led to an increase in intracellular Ca2+ levels or that glucose-stimulated insulin secretion was enhanced through activating glucose transporter-2 (GLUT-2) receptors. In our work, we rigorously examined the chemical and biological properties of giloy and mangiferin. Clinical study on the effect of mangiferin and giloy combined extract solution in type 2 diabetic subjects and determine the level of Fasting Blood sugar, insulin and HbA1c in type 2 diabetic subjects before and after therapy.   Materials and Methods: A randomized cross-sectional study was conducted on type 2 diabetic subjects. Study design with group 1 diabetic subjects (n=45) of FBS less than or equal to 160 mg/dl) and diabetic subjects group 2 (n=49) of FBS more than 160 mg/dl were included with regular antidiabetic drugs; in addition, for the period 30 days, twice a day, 500 mg mangiferin and 500 mg giloy extract was given to group 1 and group 2. The difference between the groups was calculated using the t-test and Mann-Whitney U test.   Results: It is evident from the statistical data a significant change seen in HbA1c levels , FBS levels  and insulin values while comparing group 1 and group 2 diabetic subjects. However, in group 1 and group 2 creatinine levels did not show much change.   Conclusion: Our study findings indicate that mangiferin and giloy extract is a better regime for the effective glycaemic control by an increase in insulin levels. Further, herbal leaf extract is a good natural source and cost-effective with no adverse side effects.