Evaluation of costs related to antimicrobial resistance of priority Gram-negative bacilli

Maria Anton, Larisa Pantea, Olga Burduniuc, Marcela Chilianu, V. Bucov, Livia Tapu
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Abstract

Introduction. Antimicrobial Resistance (AMR) is one of the most serious threats to global public health, causing over 700 thousand deaths annually. In addition to the social burden, AMR generates high medical costs, and estimating these at the hospital level has been the subject of research in many international studies. Material and methods. A comprehensive study was conducted, encompassing 172 cases of invasive infections recorded in patients hospitalized at the “Timofei Mosneaga” Republican Clinical Hospital, from which strains of antimicrobial-resistant E. coli, K. pneumoniae, A. baumannii, and P. aeruginosa were isolated in the years 2019-2021. Based on data regarding the duration of hospitalization, treatment costs, and expenses for investigations, indicators such as average cost, the median, minimum and maximum values of treatment, including the cost of antibiotics and laboratory analyses, were calculated. Results. The economic impact indicators of AMR at the hospital level include: the duration of hospitalization, the total costs of a treated case, the costs of antibiotics, and the costs of laboratory analyses. In the structure of microorganisms isolated from the patients included in the study, K. pneumoniae predominates, accounting for 44.2%, and the total treatment cost for this organism was the highest at 202731.5 dollars. The maximum duration of hospitalization was recorded in patients from whom A. baumannii was isolated (27.7 days). Conclusions. The resistance of strains isolated from patients has directly contributed to the extension of the hospitalization period. The resistance of A. baumannii and K. pneumoniae species has predominantly led to the increase in the economic burden of AMR.
重点革兰氏阴性杆菌抗药性相关成本评估
导言。抗菌药物耐药性(AMR)是全球公共卫生面临的最严重威胁之一,每年造成 70 多万人死亡。除社会负担外,AMR 还会产生高昂的医疗费用,在医院层面估算这些费用一直是许多国际研究的主题。材料和方法。我们开展了一项综合研究,涵盖了 "蒂莫菲-莫斯内阿加 "共和国临床医院住院病人的 172 例侵入性感染病例,在 2019-2021 年期间,从这些病例中分离出了耐抗菌素大肠杆菌、肺炎克氏菌、鲍曼不动杆菌和铜绿假单胞菌。根据住院时间、治疗费用和检查费用的相关数据,计算出平均费用、中位数、最低值和最高值等治疗指标,包括抗生素和实验室分析的费用。结果。AMR在医院层面的经济影响指标包括:住院时间、治疗病例的总费用、抗生素费用和实验室分析费用。在从研究对象中分离出的微生物结构中,肺炎克氏菌占主导地位,占 44.2%,这种微生物的治疗总费用最高,为 202731.5 美元。在分离出鲍曼不动杆菌的患者中,住院时间最长(27.7 天)。结论从患者体内分离出的菌株的耐药性直接导致了住院时间的延长。鲍曼尼氏菌和肺炎双球菌的耐药性主要导致了 AMR 经济负担的增加。
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