Chemerin in Obese Patients with Nonalcoholic Fatty Liver Disease with or without Prediabetes

V. Karamfilova, Iveta Nedeva, Y. Assyov, A. Gateva, T. Velikova, N. Cherkezov, L. Mateva, Z. Kamenov
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Abstract

Chemerin is one of the recently discovered adipokines closely related with white adipose tissue and insulin resistance (IR) in obesity, type 2 diabetes mellitus (T2DM), and nonalcoholic fatty liver disease (NAFLD), but some of these data remain controversial. This study evaluated the relationship between serum chemerin levels, prediabetes and other biochemical and clinical parameters in obese patients with NAFLD. A total of 79 obese NAFLD patients without ($n=41$) and with prediabetes ($$n=38$$) were included. Serum chemerin was measured using ELISA method. Chemerin correlated with body mass index (BMI) ($$r=0.320$$, $$p<0.01$$), hip circumference ($$r=0.296$$, $$p<0.05$$) and visceral adiposity index (VAI) ($$r=0.297$$, $$p<0.05$$). Chemerin strongly correlated with hepatic steatosis index (HSI) ($$r=0.550$$, $$p<0.01$$). Chemerin is adipokine, which has a significant, but yet not unequivocal role in the metabolic process related with obesity, insulin resistance and NAFLD. In this study we were not able to find an association of serum chemerin levels and prediabetes. There were correlations with BMI, hip circumference, Visceral adiposity index and Hepatic steatosis index.
Chemerin 在伴有或不伴有糖尿病前期的非酒精性脂肪肝肥胖患者中的应用
螯合素是最近发现的一种脂肪因子,与肥胖、2 型糖尿病(T2DM)和非酒精性脂肪肝(NAFLD)中的白色脂肪组织和胰岛素抵抗(IR)密切相关,但其中一些数据仍存在争议。本研究评估了非酒精性脂肪肝肥胖患者血清螯合素水平、糖尿病前期及其他生化和临床参数之间的关系。研究共纳入了79名非酒精性脂肪肝肥胖患者,其中包括无糖尿病(41人)和有糖尿病前期(38人)的患者。采用酶联免疫吸附法测定血清螯合素。螯合素与体重指数(BMI)($$r=0.320$$,$p<0.01$$)、臀围($$r=0.296$$,$p<0.05$$)和内脏脂肪指数(VAI)($$r=0.297$$,$p<0.05$$)相关。Chemerin与肝脏脂肪变性指数(HSI)密切相关($$r=0.550$$,$$p<0.01$$)。Chemerin是一种脂肪因子,在与肥胖、胰岛素抵抗和非酒精性脂肪肝有关的代谢过程中起着重要的作用,但作用尚不明确。在这项研究中,我们未能发现血清螯合素水平与糖尿病前期有关联。但与体重指数、臀围、内脏脂肪指数和肝脏脂肪变性指数存在相关性。
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