STUDY OF THE EFFECT OF CRYOPROTECTORS ON THE SIZE AND SHAPE OF CINNARIZINE AND POLY-D,L-LACTIDE-CO-GLYCOLIDE MICROPARTICLES.

Abstract

In a traditional drug delivery system, it is difficult to achieve precise control of the drug release rate and the drug release site. Poly-D,L-lactide-co-glycolide is one of the most frequently studied biodegradable polymeric drug carriers for drug delivery to target organs. Biodegradable polymers must have good biocompatibility. Targeted delivery of drugs obtained using modern technologies can provide a new therapeutic strategy for more localized treatment of diseases, potentially provide systemic delivery of drugs, reduce the dose of the administered drug and its possible side effects on the patient. In the experiment, we obtained microparticles based on cinnarizine with poly-D,L-lactide-co-glycolide using the co-precipitation method. The physicochemical characteristics of microparticles are of key importance for understanding their properties for further use in pharmaceuticals, since they can have different effects on the target organ due to their unique properties. The study of the dispersed composition of the obtained samples of cinnarizine microparticles based on poly-D,L-lactide-co-glycolide was carried out using photon correlation spectroscopy on a Photocor-Complex installation (Antek-97, Russia). The size and shape of microparticles explain their ability to penetrate blood vessels, tissues and target cells of target organs. The purpose of this work was to determine the effect of various cryoprotectants on the size and shape of cinnarizine microparticles at different ratios to poly-D,L-lactide-co-glycolide. Under experimental conditions, a cryoprotector was selected. As a result of the tests, it was determined that the nature of the cryoprotector affects the size and shape of the resulting particles - the optimal ratio of cinnarizine and poly-D,L-lactide-co-glycolide is 1:3, which produces microparticles 104 nm in size, spherical in shape, having a uniform distribution in the sample.