Zebrafish as a promising model for investigating biological activities of ginseng species—a review

Meijie Yu, Lulu Wang, Haiqing Luo, Bo Yang, Li Li, Jiaxin Dong, Xianghe Meng, Mengmeng Sun, Min He
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Abstract

Plants of the ginseng species have a long history with broad traditional applications, as these are recognized as precious tonic herbal medicines since ancient times. More and more multiple chemical constituents and pharmacological activities have been confirmed and discovered recently. Owing to its advantages, such as intuitiveness, cheap, easy to operate, and high-throughput screening, zebrafish has become a very popular model at present. Recently, more and more toxicity tests, bio-activity evaluation, and mechanism studies have been achieved via zebrafish models, many of which were focused on the nature of products, including monomers, extracts, and formulas from ginseng species. This review summarizes the recent pharmacological studies achieved by embryos, larvae, and adult zebrafish. This review provides a theoretical basis for the rational use of ginseng species plants, thus providing guidance for a better rational utilization and the potential innovative product development of ginseng species plants.
斑马鱼作为研究人参生物活性的一种有前途的模型--综述
人参属植物历史悠久,传统应用广泛,自古以来就被视为珍贵的滋补药材。近年来,越来越多的多种化学成分和药理活性被证实和发现。由于斑马鱼具有直观、廉价、易于操作和高通量筛选等优点,目前已成为非常受欢迎的模型。近年来,越来越多的毒性试验、生物活性评价和机理研究通过斑马鱼模型得以实现,其中许多研究集中在人参单体、提取物和配方等产品的性质方面。本综述总结了最近通过胚胎、幼虫和成年斑马鱼进行的药理学研究。本综述为合理利用人参属植物提供了理论依据,从而为更好地合理利用人参属植物和潜在的创新产品开发提供指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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