Chromosomal, Gestational, and Neonatal Outcomes of Embryos Classified as a Mosaic by Preimplantation Genetic Testing for Aneuploidy

M. Viotti, E. Greco, James A. Grifo, M. Madjunkov, Clifford Librach, M. Çetinkaya, S. Kahraman, Pavel Yakovlev, Nikolay Kornilov, Laura Corti, A. Biricik, E. Cheng, Ching-Ya Su, Maw-Sheng Lee, Michael D. Bonifacio, Amber R. Cooper, Darren K. Griffin, Diane Y. Tran, Purvi Kaur, Frank L. Barnes, C. Zouves, A. Victor, A. Besser, S. Madjunkova, F. Spinella
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Abstract

(Abstracted from Fertil Steril 2023;120(5):957) Chromosomal segregation errors during mitosis can result in embryonic mosaicism, a phenomenon where different chromosomal copy numbers exist within a single embryo. Preimplantation genetic testing for aneuploidy (PGT-A) of multicellular biopsies can produce intermediate copy numbers in these cases, where some cells are disomic and some show monosomy or trisomy.
通过植入前非整倍体基因检测被归类为马赛克胚胎的染色体、妊娠和新生儿结果
(摘自 Fertil Steril 2023;120(5):957)有丝分裂过程中的染色体分离错误会导致胚胎嵌合,这是一种在单个胚胎中存在不同染色体拷贝数的现象。对多细胞活检组织进行非整倍体植入前基因检测(PGT-A)可在这些病例中产生中间拷贝数,即一些细胞为双倍体,一些细胞为单倍体或三倍体。
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