Resveratrol activity on guinea pig isolated trachea from normal and albumin-sensitized animals

Abstract

The relaxant effect of resveratrol on guinea pig isolated trachea (EC50=100 μM) was not due to interactions with histaminergic or cholinergic systems, but appeared to be influenced by beta-blockers, indomethacin and mepacrine. Antigen-induced contraction on sensitized trachea was partially antagonized by resveratrol. Resveratrol action may be partially related to arachidonic acid metabolism.