Effect of Vaginal Progesterone after tocolytic therapy in threatened preterm labor.

Abstract

: Background: Preterm labor, accounts for the vast majority of infant mortality and morbidity. One of perinatal care primary goals is now the prevention of preterm labor. Aim: to determine whether vaginal progesterone maintenance medication could lengthen the latency period following a successful episode of preterm labor, this study examined this possibility. Methods: The women were split into two groups when the uterine contractions stopped: 50 patients made up the first group (the study group). A micronized vaginal progesterone supplement was administered to women daily in doses of 200 mg. Progesterone vaginal suppository was continued, and the women were told to reduce their physical activity, until 36 weeks of gestation. There were 50 patients in the second group (the control group). In addition to being told to minimize their physical activity, women were not offered any medicines or follow-up care. Patients were kept in the hospital if labor pain persisted; otherwise, if they were stable, they were released . Results: the study discovered that vaginal progesterone lower the risk of labor before 37 weeks of gestation for women who are more likely to high risk for preterm labor. Accordingly, treatment with progesterone agents to lessen preterm birth complications should continue to women who are at risk. Conclusion: In this study, it was discovered that preventive treatment of 200 mg vaginal suppositories of progesterone following successful tocolysis was linked to a longer gestation period and improved fetal outcomes in high-risk patients.