GSTP, GSTT1, XRCC1 and CASP8 genetic variations are associated with human papillomavirus in women with cervical cancer from Zimbabwe

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-02-26 DOI:10.2217/fvl-2023-0154

Oppah Kuguyo, Racheal S Dube Mandishora, N. Soko, Takudzwa Magwaku, A. Matimba, C. Dandara

引用次数: 0

Abstract

Aim: Investigate the role of host genetic variations in high-risk human papillomaviruses (HR-HPVs). Methods: This cross-sectional study recruited 238 cervical cancer patients. Variants in transport (ABCC2), xenobiotic metabolism ( GSTP, GSTT1, GSTM1, NQO1), DNA repair ( ERCC1, XRCC1), immune response ( TLR4) and apoptosis ( CASP8, FASL, p53) genes were characterized. Tumor DNA was genotyped for 14 HR-HPVs. Results: GSTP rs1695GG, XRCC1 rs1799782TT and GSTT1 del/del were associated with HPV51 (odds ratio [OR]: 3.9; 95% confidence interval [CI]: 1.3–11.7; p = 0.02) and HPV58 (OR: 2.4; 95% CI: 1.2–5.8; p = 0.048), respectively. CASP8 rs3834129del/del was associated with HPV16/18 (OR: 2.7; 95% CI: 1.2–6.0; p = 0.017) and HPV monoinfections (OR: 2.3; 95% CI: 1.2–4.4; p = 0.008). Conclusion: GSTP, GSTT1, XRCC1 and CASP8 variants were associated with HPV-positivity. With further research, a genetic-based screening tool can be developed, to use with HPV vaccines toward preventing cervical cancer.

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津巴布韦宫颈癌妇女的 GSTP、GSTT1、XRCC1 和 CASP8 基因变异与人类乳头瘤病毒的关系

目的：研究宿主基因变异在高危人乳头瘤病毒（HR-HPVs）中的作用。研究方法这项横断面研究招募了 238 名宫颈癌患者。对转运（ABCC2）、异生物代谢（GSTP、GSTT1、GSTM1、NQO1）、DNA 修复（ERCC1、XRCC1）、免疫反应（TLR4）和细胞凋亡（CASP8、FASL、p53）基因的变异进行了鉴定。对肿瘤 DNA 进行了 14 种 HR-HPV 基因分型。结果显示GSTP rs1695GG、XRCC1 rs1799782TT 和 GSTT1 del/del 分别与 HPV51（几率比 [OR]：3.9；95% 置信区间 [CI]：1.3-11.7；p = 0.02）和 HPV58（OR：2.4；95% CI：1.2-5.8；p = 0.048）相关。CASP8 rs3834129del/del 与 HPV16/18（OR：2.7；95% CI：1.2-6.0；p = 0.017）和 HPV 单感染（OR：2.3；95% CI：1.2-4.4；p = 0.008）相关。结论GSTP、GSTT1、XRCC1 和 CASP8 变体与 HPV 阳性有关。通过进一步研究，可以开发出一种基于基因的筛查工具，与 HPV 疫苗一起用于预防宫颈癌。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.