Atypical neoplastic solitary focal uptake of 18F-PSMA-1007 in PET/CT in patients with biochemically recurrent prostate cancer

T. L. Antonevskaya, A. Khalimon, M. M. Khodzhibekova, L. U. Atakishieva, G. F. Khamadeeva, D. Y. Khodakova, T. N. Lazutina, I. V. Pylova, N. Volchenko, A. V. Leontyev
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Abstract

It is established that prostate-specific membrane antigen (PSMA), despite its name, is expressed in many tissues other than the prostate gland, both within physiological conditions and in various pathological processes. Additionally, apart from prostate cancer, other malignant tumors are characterized by increased PSMA expression which, according to many authors, is associated with neoangiogenesis. These factors are reflected in the results of PSMA-radioligand imaging and require comprehensive approach to image interpretation including evaluation of computed tomography and magnetic resonance semiotics. In addition, rare cases of distant visceral prostate cancer metastasis in the form of solitary lesions also should be considered during interpretation of the results of radiologic imaging including positron emission tomography/computed tomography.We present two clinical cases in which positron emission tomography/computed tomography revealed solitary foci of pathological 18F-PSMA-1007 uptake outside the areas of typical metastatic spread (with exception of advanced disease) of prostate cancer, specifically in the stomach wall and the left cerebellar hemisphere. In the first case histological examination results revealed a metachronous low grade neuroendocrine tumor of the stomach, in the second case a metastatic lesion of the cerebellum was diagnosed as part of the underlying disease.
生化复发前列腺癌患者 PET/CT 中 18F-PSMA-1007 的非典型新生物单发灶摄取
前列腺特异性膜抗原(PSMA)虽然名为前列腺特异性膜抗原,但它在前列腺以外的许多组织中都有表达,无论是在生理条件下还是在各种病理过程中。此外,除前列腺癌外,其他恶性肿瘤也有 PSMA 表达增加的特点,许多学者认为这与新血管生成有关。这些因素都反映在 PSMA-放射配体成像的结果中,需要对图像进行综合解读,包括对计算机断层扫描和磁共振符号学进行评估。此外,在解读包括正电子发射断层扫描/计算机断层扫描在内的放射成像结果时,也应考虑以单发病灶形式出现的前列腺癌远处内脏转移的罕见病例。我们介绍了两个临床病例,在这两个病例中,正电子发射断层扫描/计算机断层扫描显示出前列腺癌典型转移扩散区域(晚期疾病除外)以外的单发病理 18F-PSMA-1007 摄取灶,特别是在胃壁和左侧小脑半球。在第一个病例中,组织学检查结果显示为胃部转移性低级别神经内分泌肿瘤;在第二个病例中,小脑转移性病变被诊断为潜在疾病的一部分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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