Unlocking the Therapeutic Potentiality of Natural Products in Cancer Therapy: A Recent Update and Current Prospects

Asma Khurshid, Rabbia Hussain, Rimsha Farooq
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Abstract

Cancer is one of the main causes of mortality that affects a large propotion of population worldwide each year. Traditional and synthetic medications are less successful in cancer treatment. The deleterious effects of synthetic compounds divert our attention toward the utilization of naturally derived compounds in current clinical research. The impact of biodiversity on population development and livelihood represents a wider area of interest that still heavily relies on natural medicines against the cure of various ailments. Since ancient times, people have been using natural plants because of their accessibility and economical affordability as a safe therapeutic alternative to traditional synthetic drugs. Currently, plants are used because of their remarkable properties in the form of staple drugs. These plants gain huge attention as a safe treatment option with anti-tumor, chemo-protective and anti-proliferative properties than conventional harmful therapeutics. The secondary metabolites extracted from medicinal plants lead to the production of innovative therapeutic strategies against cancer and other diseases. Targeted delivery of pharmaceuticals agents, through chemical and conventional methods is a significant challenge. The discovery of nano-vectors provides a solution to this issue with the innovation of plant-based nanoparticles have been manufactured using an ecologically sound method. Based on the highlights provided, the current review provides updated knowledge on diverse aspects of medicinal plants including challenges, significance and their role as a potential therapeutic agent against the treatment of various diseases, especially cancers. This subsequent review entails and clarifies the benefits of phytochemicals extracted from Asian medicinal plants due to their imperative values in cancer treatment and other pharmacological targets. The recent discoveries and findings linked to the understanding of medicinal drugs with significance on wide range of phytochemical constituents or secondary metabolites are a current attempt to update our knowledge towards the progress of natural therapeutics novel strategies.
发掘天然产品在癌症治疗中的治疗潜力:最新进展与前景
癌症是导致死亡的主要原因之一,每年影响着全球大量人口。传统药物和合成药物在治疗癌症方面的成功率较低。合成化合物的有害影响将我们的注意力转移到目前临床研究中对天然化合物的利用上。生物多样性对人口发展和生计的影响是一个更广泛的关注领域,在治疗各种疾病方面仍然严重依赖天然药物。自古以来,人们一直在使用天然植物,因为它们容易获取且经济实惠,是传统合成药物的安全治疗替代品。目前,植物因其卓越的特性以主食药物的形式被使用。与传统的有害疗法相比,这些植物具有抗肿瘤、化疗保护和抗增生的特性,是一种安全的治疗选择,因此受到了极大的关注。从药用植物中提取的次生代谢物可用于生产抗癌和其他疾病的创新治疗策略。通过化学和传统方法靶向递送药剂是一项重大挑战。纳米载体的发现为这一问题提供了解决方案,它采用生态无害的方法,创新性地制造出了基于植物的纳米颗粒。根据所提供的要点,本综述提供了药用植物各方面的最新知识,包括挑战、意义及其作为治疗各种疾病(尤其是癌症)的潜在治疗剂的作用。随后的综述阐述了从亚洲药用植物中提取的植物化学物质的益处,以及它们在癌症治疗和其他药理目标方面的重要价值。最近的发现和研究结果与对各种植物化学成分或次生代谢物的药用药物的理解有关,是当前更新我们的知识以促进自然疗法新策略的尝试。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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