IN VIVO EVALUATION OF ANTIDIARRHEAL ACTIVITY AND FORMULATION OF A FLOUR BASED ON EXTRACTS FROM THE LEAVES OF COMBRETUM GRANDIFLORUM G. DON (COMBRETACEAE)

Deguenon Memonsso Pauline Pierrette, Ombouma Joanna Grace, Houngbeme Gouton Alban, Ahoyo Carlos Cedric, Gbaguidi Ahokanou Fernand, Houinato Marcel Romuald Benjamin
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Abstract

Althoughmany conventional antidiarrheal agents are available, the inherenttoxicityof thesedrugsprovides an avenue to explore for safe and effective alternative medications. The objective of thisstudyis to evaluate in vivo the antidiarrhealactivity of extractsfrom the leaves of Combretumgrandiflorum and to formulate an antidiarrhealflour.The antidiarrhealactivity of Combretumgrandiflorumextractswascarried out usingmodels of castor oil-induceddiarrhea, castor oil-induced anti-enteropolling and intestinal transit. The formulation of the antidiarrhealflourwas made following the classic CCC calculationmethod. The results show a significantreduction (p˂0.01) in the frequency of wetstools and water content of diarrhea, intestinal motility, intestinal fluid accumulation and a delay in the onset of diarrhea by compared to controls, wereobserved in micetreatedwith the aqueousextract of Combretumgrandiflorum. Furthermore, the test batchestreatedwith the hydroethanolicextract and the referencemolecule (loperamide), no emission of diarrhealstools, no mass of freshdiarrhealstools, wasobserved. However, thiseffect of loperamideisstatisticallyidentical to that of the hydroethanolicextract. The formulation of antidiarrhealflourwith the hydroethanolicextract of Combretumgrandiflorumwillprovide an antidiarrhealfoodwith good nutritional value and acceptable rheologicalproperties. Additionalresearchisthereforenecessary to findflours to resolvediarrheaproblems.
腹泻活性的体内评估及基于大花金合欢叶提取物(金合欢科)的面粉配方
虽然有许多传统的止泻药,但这些药物的固有毒性为探索安全有效的替代药物提供了一条途径。本研究的目的是评估大花金合欢叶提取物的体内止泻活性,并配制一种止泻药粉。按照经典的 CCC 计算方法配制了止泻药水。结果表明,与对照组相比,用Combretumgrandiflorum水提取物处理的蝙蝠在湿凳频率、腹泻含水量、肠蠕动、肠液积聚和腹泻开始时间延迟方面都有明显的降低(pË'0.01)。此外,用水乙醇提取物和参比分子(洛哌丁胺)处理的试验蝙蝠没有出现腹泻症状,也没有出现大量新鲜腹泻症状。然而,洛哌丁胺的效果与水乙醇提取物的效果在统计学上是相同的。用大叶黄杨的水乙醇提取物配制止泻药水,将提供一种营养价值高、流变特性可接受的止泻食品。因此,有必要进行更多的研究,以找到解决腹泻问题的面粉。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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