Investigating the effect of Aloe vera on the prevention and treatment of radiotherapy-induced oral mucositis in patients with head-and-neck cancer

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Journal of Research in Medical Sciences Pub Date : 2024-03-01 DOI:10.4103/jrms.jrms_115_23

Nadia Najafizade, Roya Mobini Dehkordi, S. Hemati

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Abstract

Oral mucositis is one of the main complications of radiotherapy (RT) while treating head-and-neck cancers and can affect the patients’ treatment process and life. Therefore, this study evaluated the effect of Aloe vera on the prevention and treatment of radiotherapy-induced oral mucositis (RIOM) in patients with head-and-neck cancer. This was a double-blind clinical trial performed in 2019 on 75 patients with head-and-neck cancer. Patients were randomly assigned to two groups receiving gargles of 5 cc Aloe vera and the same dose of placebo mouthwash three times a day, respectively. Then, the incidence and severity of RIOM were evaluated and compared between the two groups over 6 weeks of RT. There was no significant difference between the two groups in terms of the severity of RIOM from the 1st to 3rd weeks of RT (P > 0.05). However, the severity of RIOM in the 4th, 5th, and 6th weeks of RT was significantly lower in the Aloe vera group compared with the placebo group (P < 0.05). According to the results of the present study, the long-term use of Aloe vera mouthwash can reduce the severity of RIOM.

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研究芦荟对预防和治疗头颈癌患者放疗引起的口腔黏膜炎的作用

口腔黏膜炎是头颈部癌症放疗（RT）的主要并发症之一，会影响患者的治疗过程和生活。因此，本研究评估了芦荟对预防和治疗头颈部癌症患者放疗引起的口腔黏膜炎（RIOM）的效果。这是一项双盲临床试验，于2019年在75名头颈癌患者中进行。患者被随机分配到两组，分别接受5cc芦荟漱口水和相同剂量的安慰剂漱口水漱口，每天三次。然后，对两组患者在 RT 6 周内的 RIOM 发生率和严重程度进行评估和比较。从 RT 的第 1 周到第 3 周，两组的 RIOM 严重程度没有明显差异（P > 0.05）。然而，芦荟组在 RT 第 4、5 和 6 周的 RIOM 严重程度明显低于安慰剂组（P < 0.05）。本研究结果表明，长期使用芦荟漱口水可以减轻 RIOM 的严重程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Research in Medical Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

2.60

自引率

6.20%

发文量

审稿时长

3-6 weeks

期刊介绍： Journal of Research in Medical Sciences, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online continuous journal with print on demand compilation of issues published. The journal’s full text is available online at http://www.jmsjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository.