Abstract 2339 The Role of an Intermediate Conformation of SHP2 in the MEK Pathway of KRAS-Driven Cancers

IF 4.8 2区生物学 Q1 Biochemistry, Genetics and Molecular Biology

Journal of Biological Chemistry Pub Date : 2024-03-01 DOI:10.1016/j.jbc.2024.107183

Daniel Shannon, Gavin Poetker, Donald Kaplan, Weston Gruber, Emmet Pease, Brandon McCloud, Jake Allen, Connor Connolly, JiaJie Diao

引用次数: 0

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摘要 2339 SHP2 的中间构象在 KRAS 驱动的癌症 MEK 通路中的作用

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biological Chemistry 生物-生化与分子生物学

CiteScore

8.50

自引率

4.20%

发文量

1233

审稿时长

63 days

期刊介绍： The Journal of Biological Chemistry welcomes high-quality science that seeks to elucidate the molecular and cellular basis of biological processes. Papers published in JBC can therefore fall under the umbrellas of not only biological chemistry, chemical biology, or biochemistry, but also allied disciplines such as biophysics, systems biology, RNA biology, immunology, microbiology, neurobiology, epigenetics, computational biology, ’omics, and many more. The outcome of our focus on papers that contribute novel and important mechanistic insights, rather than on a particular topic area, is that JBC is truly a melting pot for scientists across disciplines. In addition, JBC welcomes papers that describe methods that will help scientists push their biochemical inquiries forward and resources that will be of use to the research community.