Fahimeh Bagheri Kholenjani, S. Shahidi, G. Vaseghi, Vahid Ashoorion, N. Sarrafzadegan, M. Siavash, M. Heidarpour, S. Shahidi, Masoumeh Sadeghi, N. Mohammadifard, M. Jorjani, M. Mobarhan, Davood Shafie, Hossein Farshidi, F. Khorvash, Mojdeh Ghabaei, Zahra Teimouri-jervekani, M. Mortazavi, V. Hajhashemi, Neda Roshanravan, Leila Yazdanpanah, M. Davari, Behzad Fatemi, Elaheh Khorasani, Ramesh Hoseinkhani, E. Zarean, Alireza Ahmadi, M. Babadi, Ahmadreza Assareh, M. Shadmani, J. Kojuri, Farimah Shirani, M. Sanjari, F. Haghighatdoost, R. Hassannejad, Elham Hashemi, M. Moaddab, A. Gheisari, Bahar Dehghan, M. Naseri, N. Ghaemi, F. Noohi, A. Haghdoost, Amin salehi-Abargouei, Sara Beigrezaie, A. Doosti-Irani, Nahid Ramezani-Jolfaie, Bijan Eraj, M. Hashemipour, E. Nematipour, M. R. Kopaei
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引用次数: 0
Abstract
This guideline is the first Iranian guideline developed for the diagnosis, management, and treatment of hyperlipidemia in adults. The members of the guideline developing group (GDG) selected 9 relevant clinical questions and provided recommendations or suggestions to answer them based on the latest scientific evidence. Recommendations include the low-density lipoprotein cholesterol (LDL-C) threshold for starting drug treatment in adults lacking comorbidities was determined to be over 190 mg/dL and the triglyceride (TG) threshold had to be >500 mg/dl. In addition to perform fasting lipid profile tests at the beginning and continuation of treatment, while it was suggested to perform cardiovascular diseases (CVDs) risk assessment using valid Iranian models. Some recommendations were also provided on lifestyle modification as the first therapeutic intervention. Statins were recommended as the first line of drug treatment to reduce LDL-C, and if its level was high despite the maximum allowed or maximum tolerated drug treatment, combined treatment with ezetimibe, proprotein convertase subtilisin/kexin type 9 inhibitors, or bile acid sequestrants was suggested. In adults with hypertriglyceridemia, pharmacotherapy with statin or fibrate was recommended. The target of drug therapy in adults with increased LDL-C without comorbidities and risk factors was considered an LDL-C level of <130 mg/dl, and in adults with increased TG without comorbidities and risk factors, TG levels of <200 mg/dl. In this guideline, specific recommendations and suggestions were provided for the subgroups of the general population, such as those with CVD, stroke, diabetes, chronic kidney disease, elderly, and women.
期刊介绍:
Journal of Research in Medical Sciences, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online continuous journal with print on demand compilation of issues published. The journal’s full text is available online at http://www.jmsjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository.