MRNA Expression of Dopamine Receptors in Peripheral Blood Lymphocytes of Social Networking Sites (SNS) Addicts: A Case-control Study

Q4 Medicine
Mahin Eslami Shahrbabki, Zahra Ramazanian Bafghi, Seyed Mojtaba MirHosseini, Ehsan Mirkamandar, A. Ahmadi
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引用次数: 0

Abstract

Background: The increasing importance of and reliance on social networking sites (SNS) has led people to frequent usage and addiction. The dopaminergic system plays a crucial role in the addiction process. Additionally, research suggests that the level of expression of brain neurotransmitter receptors may be reflected in peripheral blood lymphocytes. Objectives: This study aimed to investigate the expression of dopamine receptors in peripheral blood lymphocytes (PBL) among SNS addicts and their relatives. Methods: The mRNA expression of dopamine D3, D4, and D5 receptors in peripheral blood lymphocytes was assessed using real-time PCR in SNS addicts (n = 10) and their first-degree relatives (n = 10) compared with normal subjects (n = 10). Results: The findings revealed a significant decrease in D5 and D4 receptor mRNA expression in the PBL of SNS addicts compared to the control group (P < 0.05). In contrast, D3 receptor mRNA levels showed no significant change (P > 0.05). First-degree relatives of SNS addicts also exhibited a significant decrease in D5 receptor mRNA levels compared to the control group (P < 0.05), but unlike SNS addicts, D4 receptor levels did not show any significant decrease. D3 levels also remained unchanged (P > 0.05). Conclusions: Based on the results of this study, considering the genetic factors that strongly influence social network addiction, necessary measures should be implemented to prevent this type of addiction in families and institutions such as schools and universities.
社交网站(SNS)成瘾者外周血淋巴细胞中多巴胺受体的 MRNA 表达:病例对照研究
背景:社交网站(SNS)的重要性和依赖性与日俱增,导致人们频繁使用并上瘾。多巴胺能系统在成瘾过程中起着至关重要的作用。此外,研究表明,大脑神经递质受体的表达水平可能反映在外周血淋巴细胞中。研究目的本研究旨在调查 SNS成瘾者及其亲属外周血淋巴细胞(PBL)中多巴胺受体的表达情况。方法采用实时 PCR 技术评估 SNS成瘾者(n = 10)及其一级亲属(n = 10)与正常人(n = 10)外周血淋巴细胞中多巴胺 D3、D4 和 D5受体 mRNA 的表达情况。结果显示研究结果显示,与对照组相比,SNS成瘾者PBL中D5和D4受体mRNA的表达量明显减少(P < 0.05)。相比之下,D3 受体 mRNA 水平无明显变化(P > 0.05)。与对照组相比,SNS成瘾者的一级亲属的D5受体mRNA水平也有显著下降(P < 0.05),但与SNS成瘾者不同的是,D4受体水平没有显著下降。D3 水平也保持不变(P > 0.05)。结论根据本研究的结果,考虑到遗传因素对社交网络成瘾的强烈影响,应采取必要措施在家庭和学校、大学等机构中预防此类成瘾。
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来源期刊
CiteScore
0.70
自引率
0.00%
发文量
18
期刊介绍: International Journal of High Risk Behaviors and Addiction is a clinical journal which is informative to all fields related to the high risk behaviors, addiction, including smoking, alcohol consumption and substance abuse, unsafe sexual behavior, obesity and unhealthy eating habits, physical inactivity, and violence, suicidal behavior, and self-injurious behaviors. International Journal of High Risk Behaviors and Addiction is an authentic clinical journal which its content is devoted to the particular compilation of the latest worldwide and interdisciplinary approach and findings including original manuscripts, meta-analyses and reviews, health economic papers, debates, and consensus statements of the clinical relevance of Risky behaviors and addiction. In addition, consensus evidential reports not only highlight the new observations, original research and results accompanied by innovative treatments and all the other relevant topics but also include highlighting disease mechanisms or important clinical observations and letters on articles published in this journal.
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