Mode of Deliveries and Perinatal Outcomes in Prenatal COVID-19 Infections

Abstract

The Royal Thai College of Obstetricians and Gynaecologists (RTCOG) clinical practice guideline (CPG) does not recommend elective Cesarean Section (CS) in case of prenatal maternal COVID-19 infections without obstetric indication. In Thailand, little is known about the mode of deliveries and perinatal outcomes in the mentioned group of patients. Therefore, this study aims to fill the gap in knowledge. The objective of this study was to compare the mode of deliveries and perinatal outcomes between pregnant women, who were infected with COVID-19 and those who were without COVID- 19 infection. The retrospective cohort study was based on data retrieved between February 1st and March 31st, 2023. The primary data was collected between July 1st, 2021, and October 31st, 2022. Women with COVID-19 infection were matched with the non-COVID-19 group in a 1:1 ratio by date at antenatal care (± 7 days) and their gestational age (± 1 week). Comparison of maternal and perinatal outcomes was made by using chi-squared, Fisher’s exact, relative risk, and t-test as appropriate in STATA software version 10.0. A total of 252 participants were recruited in this study, with 126 patients in each group. Demographic data between the two groups were comparable except for previous CS. The CS rates in the COVID-19 and non-COVID-19 groups were 46.03% and 30.95%, respectively, with p = 0.009. The significantly increased relative risk of CS in COVID-19 was 1.49 (95%CI, 1.07 to 2.05, p = 0.02). Eight women out of 126 had undergone CS with a “COVID-19 infection” indication (p = 0.007). The length of the maternal hospital stay was comparable. No serious maternal complications were observed. Perinatal outcomes were similar among the two groups, except for neonatal jaundice (p = 0.029), with no reports of COVID-19 infections in delivery-related personnel. Prenatal COVID-19 infections lead to an increase in CS rate, while perinatal morbidities were comparable in both groups, with COVID-19 and non-COVID-19. The RTCOG’s CPG should be modified.