Mana Shojapour, Seyedeh Maryam Hosseinikhah, Mehrnoush Sohrab, Parastoo Karimi Aliabadi, Zahra Kashi, T. Jamialahmadi, Zahra Hosseini-khah, A. Sahebkar
{"title":"Curcumin as a Potential Candidate for Patients with COVID-19 Infection\nand Diabetes: A Review","authors":"Mana Shojapour, Seyedeh Maryam Hosseinikhah, Mehrnoush Sohrab, Parastoo Karimi Aliabadi, Zahra Kashi, T. Jamialahmadi, Zahra Hosseini-khah, A. Sahebkar","doi":"10.2174/0126667975292793240320052355","DOIUrl":null,"url":null,"abstract":"\n\nCOVID-19 causes a range of illnesses, from mild symptoms resembling the common cold\nto severe pulmonary damage leading to Acute Respiratory Distress Syndrome (ARDS). Researchers\nworldwide are actively searching for the most effective medications with minimal side effects for\ntreating COVID-19. This review aimed to discuss the therapeutic potential of Curcumin (CUR) in\nmanaging COVID-19 infection in patients with comorbidities, such as Diabetes Mellitus (DM), as\nwell as the underlying mechanisms of action responsible for CUR's anti-inflammatory and immunomodulatory\neffects. Given the natural origin and fewer adverse effects of herbal and medicinal\nplants, many researchers have turned their attention to exploring their therapeutic properties. Turmeric,\nthe main source of polyphenol CUR, has long been recognized for its beneficial pharmacological\neffects in traditional Ayurveda medicine in China and has recently gained attention from scientists.\nThe study reviewed various types of studies investigating the antiviral activity of CUR. Among the\n16 studies reviewed, 4 were computational studies, 2 were in vitro studies, and the remaining 10\nwere clinical trials. Among the 10 recent studies, 4 studies focused on patients with COVID-19 who\nhad diabetes as an underlying condition. The findings from these studies suggested that CUR is a\nsafe and pleiotropic molecule with multiple effects on intracellular signaling pathways, including\nalterations in cell growth, apoptosis, inflammation, and oxidation.\n","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":"69 10","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Coronaviruses","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0126667975292793240320052355","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
COVID-19 causes a range of illnesses, from mild symptoms resembling the common cold
to severe pulmonary damage leading to Acute Respiratory Distress Syndrome (ARDS). Researchers
worldwide are actively searching for the most effective medications with minimal side effects for
treating COVID-19. This review aimed to discuss the therapeutic potential of Curcumin (CUR) in
managing COVID-19 infection in patients with comorbidities, such as Diabetes Mellitus (DM), as
well as the underlying mechanisms of action responsible for CUR's anti-inflammatory and immunomodulatory
effects. Given the natural origin and fewer adverse effects of herbal and medicinal
plants, many researchers have turned their attention to exploring their therapeutic properties. Turmeric,
the main source of polyphenol CUR, has long been recognized for its beneficial pharmacological
effects in traditional Ayurveda medicine in China and has recently gained attention from scientists.
The study reviewed various types of studies investigating the antiviral activity of CUR. Among the
16 studies reviewed, 4 were computational studies, 2 were in vitro studies, and the remaining 10
were clinical trials. Among the 10 recent studies, 4 studies focused on patients with COVID-19 who
had diabetes as an underlying condition. The findings from these studies suggested that CUR is a
safe and pleiotropic molecule with multiple effects on intracellular signaling pathways, including
alterations in cell growth, apoptosis, inflammation, and oxidation.