Ethyl Acetate Fraction of Momordica Charantia L. Fruits Induce the Phagocytosis Activity and Capacity of Rat Peritoneal Macrophages

Rachmi Ridho, C. Chaidir, Lusi Nursilawati Syamsi, B. Priosoeryanto, E. Mumpuni, S. Abdillah
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Abstract

Phagocytosis is one of the body's immune mechanisms in the elimination of antigens, including bacteria. Its mechanism is affected by many factors, such as the inducers. The present study aims to elaborate on the effect of ethyl acetate fraction of Momordica charantia L fruits on the activity and capacity of rat peritoneal macrophages on a non-A Staphylococcus aureus, including the white blood cell percentage. A series of M. charantia ethyl acetate extract concentrations of 25 mg/kg BW, 50 mg/kg BW, and 100 mg/kg BW were used to identify the phagocytosis activity and capacity, as well as the percentage of white blood cells (WBC). The result showed that the concentration of 50 mg/kg BW had the highest phagocytic activity and capacity compared to other concentrations (P < 0.05), while for the WBC percentage, there were no significant differences among the concentrations (P > 0.05). The conclusion of the present study is M. charantia ethyl acetate extract has the potential to be used as a natural immunostimulant.
醋酸乙酯萃取物诱导大鼠腹膜巨噬细胞的吞噬活性和能力
吞噬作用是人体清除细菌等抗原的免疫机制之一。其机制受多种因素影响,如诱导剂。本研究旨在阐述 Momordica charantia L 果实乙酸乙酯部分对大鼠腹腔巨噬细胞对非 A 型金黄色葡萄球菌的活性和能力(包括白细胞百分比)的影响。研究人员使用一系列浓度分别为 25 毫克/千克体重、50 毫克/千克体重和 100 毫克/千克体重的山毛桃乙酸乙酯提取物来鉴定大鼠腹腔巨噬细胞对非 A 型金黄色葡萄球菌的吞噬活性和能力以及白细胞百分比。结果表明,与其他浓度相比,50 毫克/千克体重的浓度具有最高的吞噬活性和能力(P < 0.05),而白细胞百分比在各浓度之间没有显著差异(P > 0.05)。本研究的结论是,M. charantia乙酸乙酯提取物具有作为天然免疫兴奋剂的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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