Alizarin Red S as a Chromogenic Agent for the Determination of Meropenem in Pharmaceutical- Formulations

Wallada H. Ibrahim, Hana Mahmood
{"title":"Alizarin Red S as a Chromogenic Agent for the Determination of Meropenem in Pharmaceutical- Formulations","authors":"Wallada H. Ibrahim, Hana Mahmood","doi":"10.33899/rjs.2024.182833","DOIUrl":null,"url":null,"abstract":"Alizarin red S (ALRS)reagent has been used for to determination of meropenem (MEP)by an easy, sensitive, and selective procedure based on an ion-pair formation reaction between ALRS and MEP in an aqueous: alcoholic medium in the ratio of 50:50 without adjustment of the acidity of the reaction medium. The linearity ranged from 1 to 50 µg /mL, molar absorptivity was 6.557 × 10 3 L.mol -1 .cm -1 ., index of Sandell’s, was 585584 µg.cm -2 , and the calculated LOD and LOQ were 0.02789 µg/mL, 0.0929 µg/mL respectively. The calculated range of relative error was from -1.022 to 0.34 % which indicates high accuracy, and the calculated range of the relative standard deviation was from 0.347 to 0.574% which indicates high precision. The method has been applied for the determination of MEP in dosage forms successfully in which the recovery ranged from 99.8 to 103.2%. The standard addition method proves no interfering effect caused by inactive ingredients involved in dosage forms of meropenem","PeriodicalId":20803,"journal":{"name":"Rafidain journal of science","volume":"36 3","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rafidain journal of science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33899/rjs.2024.182833","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Alizarin red S (ALRS)reagent has been used for to determination of meropenem (MEP)by an easy, sensitive, and selective procedure based on an ion-pair formation reaction between ALRS and MEP in an aqueous: alcoholic medium in the ratio of 50:50 without adjustment of the acidity of the reaction medium. The linearity ranged from 1 to 50 µg /mL, molar absorptivity was 6.557 × 10 3 L.mol -1 .cm -1 ., index of Sandell’s, was 585584 µg.cm -2 , and the calculated LOD and LOQ were 0.02789 µg/mL, 0.0929 µg/mL respectively. The calculated range of relative error was from -1.022 to 0.34 % which indicates high accuracy, and the calculated range of the relative standard deviation was from 0.347 to 0.574% which indicates high precision. The method has been applied for the determination of MEP in dosage forms successfully in which the recovery ranged from 99.8 to 103.2%. The standard addition method proves no interfering effect caused by inactive ingredients involved in dosage forms of meropenem
茜素红 S 作为致色剂测定药物制剂中的美罗培南
茜素红 S(ALRS)试剂用于美罗培南(MEP)的测定,该方法简便、灵敏、选择性好,ALRS与MEP在水:醇介质中以50:50的比例发生离子对反应,无需调节反应介质的酸度。线性范围为 1 至 50 µg /mL,摩尔吸收率为 6.557 × 10 3 L.mol -1 .cm -1 .,桑德尔指数为 585584 µg.cm -2 ,计算的最低检测限和最低定量限分别为 0.02789 µg/mL 和 0.0929 µg/mL。相对误差的计算范围为-1.022%~0.34%,准确度较高;相对标准偏差的计算范围为 0.347%~0.574%,精密度较高。该方法被成功地用于测定剂型中的 MEP,回收率在 99.8%至 103.2%之间。标准添加法证明,美罗培南剂型中的非活性成分不会产生干扰效应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信