Estimation of the Levels of UDP Glucuronosyltransferase 2 Activity and some Vitamins (B12, B17, C and D) for Patients with Colon Cancer

Rafidain journal of science Pub Date : 2024-03-31 DOI:10.33899/rjs.2024.182820

parween Ismail, Lutfia Hassan, Pshtiwan Yousif

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Abstract

One of the most prevalent types of cancer in humans and a well-known cause of mortality is colon cancer. This study aimed to measure the serum levels of UDP glucuronosyltransferase vitamins (B12, B17, C and D) in patients with colon cancer and to determine how these levels affect the course of the disease. The participants in the current study include 45 healthy people (mean age = 62.03±12.3 yrs.) who serve as a comparison group and 65 subjects with subjectively diagnosed colon cancer (mean age = 64.03±12.2 yrs.). The serum UDP glucuronosyltransferase 2B17, Vitamin B12, Vitamin D, and Vitamin C levels were among the determined biochemical markers . When colon cancer patients were compared to the control group, UDP glucuronosyltransferase 2B17 levels were significantly higher (P < 0.0001). In comparison to the control group, the serum Vitamin B12, Vitamin D, and Vitamin C levels in colon cancer patients were all considerably lower (P < 0.0001), P < 0.001, and P< 0.05, respectively). In our investigation, a marker for colon cancer was shown to be an increase in blood UDP glucuronosyltransferase 2B17 and a decrease in vitamin B12

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结肠癌患者体内 UDP 葡萄糖醛酸转移酶 2 活性和某些维生素（B12、B17、C 和 D）水平的评估

结肠癌是人类最常见的癌症之一，也是众所周知的致死原因。本研究旨在测量结肠癌患者血清中 UDP 葡萄糖醛酸基转移酶维生素（B12、B17、C 和 D）的水平，并确定这些水平如何影响病程。本次研究的参与者包括作为对比组的 45 名健康人（平均年龄为 62.03±12.3 岁）和 65 名主观诊断为结肠癌的受试者（平均年龄为 64.03±12.2 岁）。测定的生化指标包括血清 UDP 葡萄糖醛酸转移酶 2B17、维生素 B12、维生素 D 和维生素 C 水平。与对照组相比，结肠癌患者的 UDP 葡萄糖醛酸转移酶 2B17 水平明显更高（P < 0.0001）。与对照组相比，结肠癌患者的血清维生素 B12、维生素 D 和维生素 C 水平均明显偏低（分别为 P < 0.0001、P < 0.001 和 P < 0.05）。在我们的研究中，结肠癌的标志物是血液中 UDP 葡萄糖醛酸转移酶 2B17 的增加和维生素 B12 的减少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Rafidain journal of science

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