A metabolic perspective to sleep genetics

IF 4.8 2区医学 Q1 NEUROSCIENCES

Current Opinion in Neurobiology Pub Date : 2024-04-05 DOI:10.1016/j.conb.2024.102874

Daniel C. Levine , Louis J. Ptáček , Ying-Hui Fu

引用次数: 0

Abstract

The metabolic signals that regulate sleep and the metabolic functions that occur during sleep are active areas of research. Prior studies have focused on sugars and nucleotides but new genetic evidence suggests novel functions of lipid and amino acid metabolites in sleep. Additional genetic studies of energetic signaling pathways and the circadian clock transcription factor network have increased our understanding of how sleep responds to changes in the metabolic state. This review focuses on key recent insights from genetic experiments in humans and model organisms to improve our understanding of the interrelationship between metabolism and sleep.

查看原文本刊更多论文

从代谢角度看睡眠遗传学

调节睡眠的新陈代谢信号和睡眠过程中的新陈代谢功能是目前活跃的研究领域。之前的研究主要集中在糖和核苷酸方面，但新的遗传学证据表明，脂质和氨基酸代谢物在睡眠中具有新的功能。对能量信号通路和昼夜节律时钟转录因子网络的其他遗传学研究增加了我们对睡眠如何响应新陈代谢状态变化的了解。本综述将重点介绍最近从人类和模式生物的遗传实验中获得的重要启示，以加深我们对新陈代谢与睡眠之间相互关系的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Opinion in Neurobiology 医学-神经科学

CiteScore

11.10

自引率

1.80%

发文量

130

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Neurobiology publishes short annotated reviews by leading experts on recent developments in the field of neurobiology. These experts write short reviews describing recent discoveries in this field (in the past 2-5 years), as well as highlighting select individual papers of particular significance. The journal is thus an important resource allowing researchers and educators to quickly gain an overview and rich understanding of complex and current issues in the field of Neurobiology. The journal takes a unique and valuable approach in focusing each special issue around a topic of scientific and/or societal interest, and then bringing together leading international experts studying that topic, embracing diverse methodologies and perspectives. Journal Content: The journal consists of 6 issues per year, covering 8 recurring topics every other year in the following categories: -Neurobiology of Disease- Neurobiology of Behavior- Cellular Neuroscience- Systems Neuroscience- Developmental Neuroscience- Neurobiology of Learning and Plasticity- Molecular Neuroscience- Computational Neuroscience