Sleep apnea and ischemic stroke— a perspective for translational preclinical modelling

IF 11.2 1区 医学 Q1 CLINICAL NEUROLOGY
I.J. Biose , A.B. Bakare , H. Wang , T.E. Gressett , G.J. Bix
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引用次数: 0

Abstract

Obstructive sleep apnea (OSA) is associated with ischemic stroke. There is, however, a lack of knowledge on the exact cause-effect relationship, and preclinical models of OSA for experimental ischemic stroke investigations are not well characterized. In this review, we discuss sleep apnea and its relationship with stroke risk factors. We consider how OSA may lead to ischemic stroke and how OSA-induced metabolic syndrome and hypothalamic-pituitary axis (HPA) dysfunction could serve as therapeutic targets to prevent ischemic stroke. Further, we examine the translational potential of established preclinical models of OSA. We conclude that metabolic syndrome and HPA dysfunction, which are often overlooked in the context of experimental stroke and OSA studies, are crucial for experimental consideration to improve the body of knowledge as well as the translational potential of investigative efforts.

睡眠呼吸暂停与缺血性中风--临床前转化模型的视角
阻塞性睡眠呼吸暂停(OSA)与缺血性中风有关。然而,人们对其确切的因果关系还缺乏了解,用于缺血性中风实验研究的 OSA 临床前模型也没有很好的特征。在本综述中,我们将讨论睡眠呼吸暂停及其与中风危险因素的关系。我们探讨了 OSA 如何导致缺血性中风,以及 OSA 引起的代谢综合征和下丘脑-垂体轴(HPA)功能障碍如何成为预防缺血性中风的治疗靶点。此外,我们还研究了已建立的 OSA 临床前模型的转化潜力。我们的结论是,代谢综合征和 HPA 功能障碍在脑卒中和 OSA 的实验研究中经常被忽视,但它们是实验中需要考虑的关键因素,可提高研究工作的知识体系和转化潜力。
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来源期刊
Sleep Medicine Reviews
Sleep Medicine Reviews 医学-临床神经学
CiteScore
20.10
自引率
3.80%
发文量
107
期刊介绍: Sleep Medicine Reviews offers global coverage of sleep disorders, exploring their origins, diagnosis, treatment, and implications for related conditions at both individual and public health levels. Articles comprehensively review clinical information from peer-reviewed journals across various disciplines in sleep medicine, encompassing pulmonology, psychiatry, psychology, physiology, otolaryngology, pediatrics, geriatrics, cardiology, dentistry, nursing, neurology, and general medicine. The journal features narrative reviews, systematic reviews, and editorials addressing areas of controversy, debate, and future research within the field.
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