{"title":"The type IVc pilus: just a Tad different","authors":"Gregory B Whitfield, Yves V Brun","doi":"10.1016/j.mib.2024.102468","DOIUrl":null,"url":null,"abstract":"<div><p>Bacteria utilize type IV pili (T4P) to interact with their environment, where they facilitate processes including motility, adherence, and DNA uptake. T4P require multisubunit, membrane-spanning nanomachines for assembly. The tight adherence (Tad) pili are an Archaea-derived T4P subgroup whose machinery exhibits significant mechanistic and architectural differences from bacterial type IVa and IVb pili. Most Tad biosynthetic genes are encoded in a single locus that is widespread in bacteria due to facile acquisition via horizontal gene transfer. These loci experience extensive structural rearrangements, including the acquisition of novel regulatory or biosynthetic genes, which fine-tune their function. This has permitted their integration into many different bacterial lifestyles, including the <em>Caulobacter crescentus</em> cell cycle, <em>Myxococcus xanthus</em> predation, and numerous plant and mammalian pathogens and symbionts.</p></div>","PeriodicalId":10921,"journal":{"name":"Current opinion in microbiology","volume":"79 ","pages":"Article 102468"},"PeriodicalIF":5.9000,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369527424000444/pdfft?md5=6a90712ed76dec20b12ea24efdd445b9&pid=1-s2.0-S1369527424000444-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in microbiology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1369527424000444","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Bacteria utilize type IV pili (T4P) to interact with their environment, where they facilitate processes including motility, adherence, and DNA uptake. T4P require multisubunit, membrane-spanning nanomachines for assembly. The tight adherence (Tad) pili are an Archaea-derived T4P subgroup whose machinery exhibits significant mechanistic and architectural differences from bacterial type IVa and IVb pili. Most Tad biosynthetic genes are encoded in a single locus that is widespread in bacteria due to facile acquisition via horizontal gene transfer. These loci experience extensive structural rearrangements, including the acquisition of novel regulatory or biosynthetic genes, which fine-tune their function. This has permitted their integration into many different bacterial lifestyles, including the Caulobacter crescentus cell cycle, Myxococcus xanthus predation, and numerous plant and mammalian pathogens and symbionts.
细菌利用 IV 型纤毛（T4P）与周围环境相互作用，促进运动、粘附和 DNA 吸收等过程。T4P 需要多亚基、跨膜的纳米机器来组装。紧密粘附（Tad）纤毛虫是一种源自古细菌的 T4P 亚群，其机制和结构与细菌 IVa 型和 IVb 型纤毛虫有显著不同。大多数 Tad 生物合成基因都由一个基因座编码，该基因座通过水平基因转移很容易获得，因此在细菌中广泛存在。这些基因座经历了广泛的结构重排，包括获得新的调控或生物合成基因，从而对其功能进行微调。这使得它们能够融入许多不同的细菌生活方式，包括新月杆菌的细胞周期、黄腐霉菌的捕食，以及许多植物和哺乳动物病原体和共生体。
期刊介绍：
Current Opinion in Microbiology is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of microbiology. It consists of 6 issues per year covering the following 11 sections, each of which is reviewed once a year:
Host-microbe interactions: bacteria
Cell regulation
Environmental microbiology
Host-microbe interactions: fungi/parasites/viruses
Antimicrobials
Microbial systems biology
Growth and development: eukaryotes/prokaryotes
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