Integration of anticancer drug ruboxyl into the membrane of fullerene-based vesicle enhances its therapeutic performance

IF 1.8 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Mendeleev Communications Pub Date : 2024-03-01 DOI:10.1016/j.mencom.2024.02.006

Olga A. Kraevaya , Ekaterina A. Khakina , Nikita A. Emelianov , Alexander F. Shestakov , Tatyana E. Sashenkova , Denis V. Mishchenko , Pavel A. Troshin

引用次数: 0

Abstract

The supramolecular complexation of anthracycline antibiotic ruboxyl with water-soluble fullerene derivative was visualized by scattering scanning near-field optical microscopy, and the effects of this complexation on the antileukemic activity in vivo were evaluated. Treatment of mice with P388 lymphocytic leukemia with ruboxyl resulted in 13% of cured animals, while similar treatment with ruboxyl–fullerene derivative combination caused 63% curing.

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将抗癌药物 ruboxyl 植入富勒烯基囊泡膜中可提高其治疗效果

通过散射扫描近场光学显微镜观察了蒽环类抗生素 ruboxyl 与水溶性富勒烯衍生物的超分子复合物，并评估了这种复合物对体内抗白血病活性的影响。用 ruboxyl 治疗患有 P388 淋巴细胞白血病的小鼠，有 13% 的动物痊愈，而用 ruboxyl 与富勒烯衍生物复合物进行类似治疗，则有 63% 的动物痊愈。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mendeleev Communications 化学-化学综合

CiteScore

3.00

自引率

21.10%

发文量

226

审稿时长

4-8 weeks

期刊介绍： Mendeleev Communications is the journal of the Russian Academy of Sciences, launched jointly by the Academy of Sciences of the USSR and the Royal Society of Chemistry (United Kingdom) in 1991. Starting from 1st January 2007, Elsevier is the new publishing partner of Mendeleev Communications. Mendeleev Communications publishes short communications in chemistry. The journal primarily features papers from the Russian Federation and the other states of the former USSR. However, it also includes papers by authors from other parts of the world. Mendeleev Communications is not a translated journal, but instead is published directly in English. The International Editorial Board is composed of eminent scientists who provide advice on refereeing policy.

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