Shifting our perspective on orphan G protein-coupled receptors

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-04-02 DOI:10.1038/s41594-024-01270-1

Nicola J. Smith, Fiona Murray

引用次数: 0

Abstract

G protein-coupled receptors (GPCRs) with no known endogenous ligand are termed orphans. Deorphanization of a GPCR involves identifying the ligand, which can be a painstaking exercise. In this Comment, we discuss the challenges in the process, its role in drug discovery and alternative approaches to characterizing orphan GPCRs.

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转变我们对孤儿 G 蛋白偶联受体的看法

没有已知内源配体的 G 蛋白偶联受体（GPCR）被称为 "孤儿"。GPCR 的非形态化涉及配体的鉴定，这可能是一项艰巨的工作。在本评论中，我们将讨论这一过程中的挑战、其在药物发现中的作用以及表征孤儿 GPCR 的替代方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.