Recyclable ionic liquid-mediated synthesis of quinazolin-4(3H)-ones under metal-free and solvent-free conditions

IF 5.4 1区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

GIANT Pub Date : 2024-03-27 DOI:10.1016/j.giant.2024.100255

Xue Ma, Peng Li, Xuerou Chen, Siqi Li, Wuji Sun, Qidi Zhong

引用次数: 0

Abstract

A metal-free and solvent-free method for the synthesis of quinazolin-4(3H)-ones is proposed by condensation cyclization of 2-aminobenzamides and aldehydes using 1-butyl-3-methylimida-zolium tetrafluoride ([Bmim]BF₄) as ionic liquid catalyst. In this reaction, [Bmim]BF₄ acts as both a catalyst and a solvent without need for additional catalysts and solvents. This method exhibits favorable functional group tolerance in substrates and affords a series of desired products in moderate to excellent yields. In addition, it is noteworthy that the reaction yield is still as high as 87% after [Bmim]BF₄ is recycled at least four times.

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在无金属和无溶剂条件下以可回收离子液体为媒介合成喹唑啉-4(3H)-酮类化合物

以 1-丁基-3-甲基四氟化亚氨基唑（[Bmim]BF4）为离子液体催化剂，通过 2-氨基苯甲酰胺和醛的缩合环化反应，提出了一种无金属、无溶剂的喹唑啉-4(3H)-酮合成方法。在该反应中，[Bmim]BF4 既是催化剂又是溶剂，无需额外的催化剂和溶剂。这种方法对底物中的官能团具有良好的耐受性，并能以中等到极高的产率得到一系列所需的产物。此外，值得注意的是，[Bmim]BF4 循环使用至少四次后，反应产率仍高达 87%。

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来源期刊

GIANT Multiple-

CiteScore

8.50

自引率

8.60%

发文量

审稿时长

42 days

期刊介绍： Giant is an interdisciplinary title focusing on fundamental and applied macromolecular science spanning all chemistry, physics, biology, and materials aspects of the field in the broadest sense. Key areas covered include macromolecular chemistry, supramolecular assembly, multiscale and multifunctional materials, organic-inorganic hybrid materials, biophysics, biomimetics and surface science. Core topics range from developments in synthesis, characterisation and assembly towards creating uniformly sized precision macromolecules with tailored properties, to the design and assembly of nanostructured materials in multiple dimensions, and further to the study of smart or living designer materials with tuneable multiscale properties.