Hypertension-specific association of cardio-ankle vascular index with subclinical left ventricular function in a Chinese population: Danyang study

IF 2.7 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Journal of Clinical Hypertension Pub Date : 2024-04-02 DOI:10.1111/jch.14803

Xue Zhang MD, Yibo Li MD, Xinyue Wang MD, Tianna Zhou MD, Yun Gao PhD, Mulian Hua MSc(Med), Siqi Zhang MSc(Med), Chao Chen MSc(Med), Xixuan Zhao MSc(Med), Anxia He MD, PhD, Junya Liang MSc, Ming Liu MD, PhD

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Abstract

The association of cardio-ankle vascular index (CAVI), with subclinical cardiac dysfunction in hypertensive patients is unclear. We aim to examine their relationship in hypertensive patients compared with that in normotensive subjects. Our study included 1887 subjects enrolled from Danyang between 2018 and 2019. CAVI was measured using VaSera VS-1500A device. We performed conventional echocardiography to measure ejection fraction (EF) and E/A, tissue Doppler to measure mitral annular early diastolic velocities (e’), and speckle-tracking to estimate left ventricular (LV) global longitudinal strain (GLS). LV mass index (76.3, 80.0, and 84.0 g/m²), and E/e’ (7.6, 8.2, and 8.8) were increased and GLS (21.1, 21.0, and 20.4%), E/A (1.2, 1.0, and 0.8) and e’ velocity (11.2, 9.4, and 8.2 cm/s) was decreased from tertiles 1–3 of CAVI on unadjusted analyses (P < .001). After adjustment for covariates, GLS, E/A, and e’ were still significantly decreased from tertiles 1–3 of CAVI (P ≤ .04). Further sensitive analyses revealed a similar association pattern for diastolic function but not systolic function. Compared with the lowest tertile, subjects with a top tertile of CAVI were at higher risk of subclinical LV systolic dysfunction in hypertensive patients (OR = 2.61; P = .005). Increased CAVI is associated with worse subclinical diastolic function. However, this relationship of CAVI to subclinical systolic function was more prominent in hypertensive patients.

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中国人群中高血压特异性心踝关节血管指数与亚临床左心室功能的关系：丹阳研究。

心踝关节血管指数（CAVI）与高血压患者亚临床心功能不全的关系尚不清楚。我们旨在研究高血压患者与正常血压受试者的关系。我们的研究纳入了2018年至2019年期间从丹阳招募的1887名受试者。使用 VaSera VS-1500A 设备测量 CAVI。我们使用常规超声心动图测量射血分数（EF）和E/A，使用组织多普勒测量二尖瓣环舒张早期速度（e'），使用斑点追踪估算左心室整体纵向应变（GLS）。在未经调整的分析中，左心室质量指数（76.3、80.0 和 84.0 g/m2）和 E/e'（7.6、8.2 和 8.8）均有所增加，而 GLS（21.1、21.0 和 20.4%）、E/A（1.2、1.0 和 0.8）和 e'速度（11.2、9.4 和 8.2 cm/s）则从 CAVI 的 1-3 级下降（P＜0.05）。

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来源期刊

Journal of Clinical Hypertension PERIPHERAL VASCULAR DISEASE-

CiteScore

5.80

自引率

7.10%

发文量

191

审稿时长

4-8 weeks

期刊介绍： The Journal of Clinical Hypertension is a peer-reviewed, monthly publication that serves internists, cardiologists, nephrologists, endocrinologists, hypertension specialists, primary care practitioners, pharmacists and all professionals interested in hypertension by providing objective, up-to-date information and practical recommendations on the full range of clinical aspects of hypertension. Commentaries and columns by experts in the field provide further insights into our original research articles as well as on major articles published elsewhere. Major guidelines for the management of hypertension are also an important feature of the Journal. Through its partnership with the World Hypertension League, JCH will include a new focus on hypertension and public health, including major policy issues, that features research and reviews related to disease characteristics and management at the population level.