Hospitalization burden associated with anus and penis neoplasm in Spain (2016-2020).

IF 4.1 4区 医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Human Vaccines & Immunotherapeutics Pub Date : 2024-12-31 Epub Date: 2024-04-01 DOI:10.1080/21645515.2024.2334001
Victor Fernandez-Alonso, Ruth Gil-Prieto, Maria Amado-Anton-Pacheco, Valentín Hernández-Barrera, Ángel Gil-De-Miguel
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引用次数: 0

Abstract

In 2020, there were approximately 50,865 anal cancer cases and 36,068 penile cancer cases worldwide. HPV is considered the main causal agent for the development of anal cancer and one of the causal agents responsible for the development of penile cancer. The aim of this epidemiological, descriptive, retrospective study was to describe the burden of hospitalization associated with anal neoplasms in men and women and with penis neoplasms in men in Spain from 2016 to 2020. The National Hospital Data Surveillance System of the Ministry of Health, Conjunto Mínimo Básico de Datos, provided the discharge information used in this observational retrospective analysis. A total of 3,542 hospitalizations due to anal cancer and 4,270 hospitalizations due to penile cancer were found; For anal cancer, 57.4% of the hospitalizations occurred in men, and these hospitalizations were also associated with significantly younger mean age, longer hospital stays and greater costs than those in women. HIV was diagnosed in 11.19% of the patients with anal cancer and 1.74% of the patients with penile cancer. The hospitalization rate was 2.07 for men and 1.45 for women per 100,000 in anal cancer and of 4.38 per 100,000 men in penile cancer. The mortality rate was 0.21 for men and 0.12 for women per 100,000 in anal cancer and 0.31 per 100.000 men in penile cancer and the case-fatality rate was 10.07% in men and 8,26% in women for anal cancer and 7.04% in penile cancer. HIV diagnosis significantly increased the cost of hospitalization. For all the studied diagnoses, the median length of hospital stays and hospitalization cost increased with age. Our study offers relevant data on the burden of hospitalization for anal and penile cancer in Spain. This information can be useful for future assessment on the impact of preventive measures, such as screening or vaccination in Spain.

西班牙与肛门和阴茎肿瘤相关的住院负担(2016-2020 年)。
2020 年,全球约有 50 865 例肛门癌病例和 36 068 例阴茎癌病例。人乳头瘤病毒被认为是肛门癌的主要致病因子,也是阴茎癌的致病因子之一。这项流行病学描述性回顾性研究旨在描述 2016 年至 2020 年西班牙男性和女性肛门肿瘤以及男性阴茎肿瘤相关的住院负担。卫生部全国医院数据监测系统(Conjunto Mínimo Básico de Datos)提供了本次观察性回顾分析所使用的出院信息。在肛门癌方面,57.4%的住院患者为男性,与女性相比,这些患者的平均年龄明显更小、住院时间更长、费用更高。11.19%的肛门癌患者和 1.74%的阴茎癌患者确诊感染了艾滋病毒。肛门癌患者的住院率为每 10 万人中男性 2.07 人,女性 1.45 人;阴茎癌患者的住院率为每 10 万人中男性 4.38 人。肛门癌的男性死亡率为每 10 万人中 0.21 人,女性为 0.12 人;阴茎癌的男性死亡率为每 10 万人中 0.31 人;肛门癌的男性病死率为 10.07%,女性为 8.26%,阴茎癌为 7.04%。艾滋病毒的诊断大大增加了住院费用。在所有研究的诊断中,住院时间和住院费用的中位数随着年龄的增长而增加。我们的研究提供了西班牙肛门癌和阴茎癌住院负担的相关数据。这些信息有助于今后评估预防措施(如在西班牙进行筛查或接种疫苗)的影响。
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来源期刊
Human Vaccines & Immunotherapeutics
Human Vaccines & Immunotherapeutics BIOTECHNOLOGY & APPLIED MICROBIOLOGY-IMMUNOLOGY
CiteScore
7.90
自引率
8.30%
发文量
489
审稿时长
3-6 weeks
期刊介绍: (formerly Human Vaccines; issn 1554-8619) Vaccine research and development is extending its reach beyond the prevention of bacterial or viral diseases. There are experimental vaccines for immunotherapeutic purposes and for applications outside of infectious diseases, in diverse fields such as cancer, autoimmunity, allergy, Alzheimer’s and addiction. Many of these vaccines and immunotherapeutics should become available in the next two decades, with consequent benefit for human health. Continued advancement in this field will benefit from a forum that can (A) help to promote interest by keeping investigators updated, and (B) enable an exchange of ideas regarding the latest progress in the many topics pertaining to vaccines and immunotherapeutics. Human Vaccines & Immunotherapeutics provides such a forum. It is published monthly in a format that is accessible to a wide international audience in the academic, industrial and public sectors.
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