Evolving Therapeutic Landscape of Intracerebral Hemorrhage: Emerging Cutting-Edge Advancements in Surgical Robots, Regenerative Medicine, and Neurorehabilitation Techniques.

IF 4.3 2区医学 Q1 CLINICAL NEUROLOGY

Translational Stroke Research Pub Date : 2025-06-01 Epub Date: 2024-04-01 DOI:10.1007/s12975-024-01244-x

Danyang Chen, Zhixian Zhao, Shenglun Zhang, Shiling Chen, Xuan Wu, Jian Shi, Na Liu, Chao Pan, Yingxin Tang, Cai Meng, Xingwei Zhao, Bo Tao, Wenjie Liu, Diansheng Chen, Han Ding, Ping Zhang, Zhouping Tang

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Abstract

Intracerebral hemorrhage (ICH) is the most serious form of stroke and has limited available therapeutic options. As knowledge on ICH rapidly develops, cutting-edge techniques in the fields of surgical robots, regenerative medicine, and neurorehabilitation may revolutionize ICH treatment. However, these new advances still must be translated into clinical practice. In this review, we examined several emerging therapeutic strategies and their major challenges in managing ICH, with a particular focus on innovative therapies involving robot-assisted minimally invasive surgery, stem cell transplantation, in situ neuronal reprogramming, and brain-computer interfaces. Despite the limited expansion of the drug armamentarium for ICH over the past few decades, the judicious selection of more efficacious therapeutic modalities and the exploration of multimodal combination therapies represent opportunities to improve patient prognoses after ICH.

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不断演变的脑出血治疗格局：手术机器人、再生医学和神经康复技术的前沿进展。

脑内出血（ICH）是最严重的中风形式，现有的治疗方案有限。随着 ICH 知识的迅速发展，手术机器人、再生医学和神经康复领域的尖端技术可能会彻底改变 ICH 的治疗方法。然而，这些新进展仍需转化为临床实践。在这篇综述中，我们探讨了几种新兴的治疗策略及其在治疗 ICH 方面面临的主要挑战，尤其关注涉及机器人辅助微创手术、干细胞移植、原位神经元重编程和脑机接口的创新疗法。尽管过去几十年来治疗 ICH 的药物种类有限，但明智地选择更有效的治疗方式并探索多模式联合疗法，是改善 ICH 患者预后的良机。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Stroke Research CLINICAL NEUROLOGY-NEUROSCIENCES

CiteScore

13.80

自引率

4.30%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Translational Stroke Research covers basic, translational, and clinical studies. The Journal emphasizes novel approaches to help both to understand clinical phenomenon through basic science tools, and to translate basic science discoveries into the development of new strategies for the prevention, assessment, treatment, and enhancement of central nervous system repair after stroke and other forms of neurotrauma. Translational Stroke Research focuses on translational research and is relevant to both basic scientists and physicians, including but not restricted to neuroscientists, vascular biologists, neurologists, neuroimagers, and neurosurgeons.