Beneficial effects of the first case of washed microbiota transplantation for postorgasmic illness syndrome: a case report.

IF 2.6 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

Sexual Medicine Pub Date : 2024-03-27 eCollection Date: 2024-04-01 DOI:10.1093/sexmed/qfae015

Yong-Xi Quan, Ye-Dong Lao, Hui-Yi Wu, Xing-Xiang He, Li-Hao Wu

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引用次数: 0

Abstract

Introduction: Postorgasmic illness syndrome (POIS) is characterized by allergic symptoms and flu-like illness after ejaculation. There are still no effective treatments for POIS.

Aim: To report the first case of washed microbiota transplantation (WMT) to treat patient with POIS.

Methods: Data were collected from a patient with POIS who had received 3 courses of WMT: self-rating scale of POIS symptoms, Self-rating Anxiety Scale, Self-rating Depression Scale, and Symptom Checklist 90. The patient's stool samples for 16sDNA sequencing were collected 1 month after WMT.

Results: POIS symptoms improved after WMT. Scores decreased from baseline after WMT: self-rating scale of POIS symptoms (before WMT, 16; after first, 16; after second, 8; after third, 9), Self-rating Anxiety Scale (45, 42.5, 37.5, 45), Self-rating Depression Scale (63.75, 58.75, 47.5, 50), and Symptom Checklist 90 (143, 140, 109, 149). Characteristics of the patient's gut microbiota changed. At the genus level, the relative abundance of beneficial bacteria increased, and some opportunistic pathogenic bacteria decreased.

Conclusion: WMT may be an effective and safe choice for the treatment of patients with POIS by changing the gut microbiota of the host.

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首例冲洗微生物群移植治疗性高潮后疾病综合征的有益效果：病例报告。

简介性高潮后疾病综合征（POIS）的特征是射精后出现过敏症状和流感样疾病。目的：报告首例洗净微生物群移植（WMT）治疗 POIS 患者的病例：方法：收集一名接受过 3 个疗程 WMT 治疗的 POIS 患者的数据：POIS 症状自评量表、焦虑自评量表、抑郁自评量表和症状核对表 90。WMT 1 个月后收集患者粪便样本进行 16sDNA 测序：结果：POIS症状在WMT治疗后有所改善。WMT后，POIS症状自评量表（WMT前，16分；第一次WMT后，16分；第二次WMT后，8分；第三次WMT后，9分）、焦虑自评量表（45分、42.5分、37.5分、45分）、抑郁自评量表（63.75分、58.75分、47.5分、50分）和症状检查表90（143分、140分、109分、149分）的得分从基线下降。患者肠道微生物群的特征发生了变化。在菌属水平上，有益菌的相对丰度增加了，而一些机会致病菌则减少了：通过改变宿主的肠道微生物群，WMT 可能是治疗 POIS 患者的一种有效而安全的选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sexual Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

5.40

自引率

0.00%

发文量

103

审稿时长

22 weeks

期刊介绍： Sexual Medicine is an official publication of the International Society for Sexual Medicine, and serves the field as the peer-reviewed, open access journal for rapid dissemination of multidisciplinary clinical and basic research in all areas of global sexual medicine, and particularly acts as a venue for topics of regional or sub-specialty interest. The journal is focused on issues in clinical medicine and epidemiology but also publishes basic science papers with particular relevance to specific populations. Sexual Medicine offers clinicians and researchers a rapid route to publication and the opportunity to publish in a broadly distributed and highly visible global forum. The journal publishes high quality articles from all over the world and actively seeks submissions from countries with expanding sexual medicine communities. Sexual Medicine relies on the same expert panel of editors and reviewers as The Journal of Sexual Medicine and Sexual Medicine Reviews.