Recent advances in patient-derived tumor organoids for reconstructing TME of head and neck cancer

IF 2.7 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine Pub Date : 2024-04-01 DOI:10.1111/jop.13532

Lin Chen, Yinyu Chen, Liangyu Ge, Qian Zhang, Jian Meng

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引用次数: 0

Abstract

Background

The differences between existing preclinical models and the tumor microenvironment in vivo are one of the significant challenges hindering cancer therapy development. Patient-derived tumor organoids (PDTO) can highly retain tumor heterogeneity. Thus, it provides a more reliable platform for research in tumor biology, new drug screening, and precision medicine.

Methods

We conducted a systematic review to summarise the characteristics of the existing preclinical models, the advantages of patient-derived tumor organoids in reconstructing the tumor microenvironment, and the latest research progress. Moreover, this study deciphers organoid culture technology in the clinical precision treatment of head and neck cancer to achieve better transformation. Studies were identified through a comprehensive search of Ovid MEDLINE (Wolters Kluwer), PubMed (National Library of Medicine), web of Science (Thomson Reuters) and, Scopus (Elsevier) databases, without publication date or language restrictions.

Results

In tumor development, the interaction between cellular and non-cellular components in the tumor microenvironment (TME) has a crucial role. Co-culture, Air-liquid interface culture, microfluidics, and decellularized matrix have depicted great potential in reconstructing the tumor microenvironment and simulating tumor genesis, development, and metastasis.

Conclusion

An accurate determination of stromal cells, immune cells, and extracellular matrix can be achieved by reconstructing the head and neck cancer tumor microenvironment using the PDTO model. Moreover, the interaction between head and neck cancer cells can also play an essential role in implementing the individualized precision treatment of head and neck cancer.

查看原文本刊更多论文

用于重建头颈部肿瘤组织间质的患者来源肿瘤器官组织的最新进展。

背景：现有临床前模型与体内肿瘤微环境之间的差异是阻碍癌症疗法开发的重大挑战之一。患者衍生肿瘤器官组织（PDTO）能高度保留肿瘤的异质性。因此，它为肿瘤生物学研究、新药筛选和精准医疗提供了更可靠的平台：我们进行了一项系统性综述，总结了现有临床前模型的特点、患者来源肿瘤器官组织在重建肿瘤微环境方面的优势以及最新的研究进展。此外，本研究还解读了类器官培养技术在头颈癌临床精准治疗中的应用，以实现更好的转化。这些研究是通过对 Ovid MEDLINE (Wolters Kluwer)、PubMed (National Library of Medicine)、web of Science (Thomson Reuters) 和 Scopus (Elsevier) 数据库的全面检索而确定的，没有出版日期或语言限制：在肿瘤发生发展过程中，肿瘤微环境（TME）中细胞和非细胞成分之间的相互作用起着至关重要的作用。共培养、气液界面培养、微流控和脱细胞基质在重建肿瘤微环境和模拟肿瘤发生、发展和转移方面具有巨大潜力：结论：使用 PDTO 模型重建头颈癌肿瘤微环境，可以准确测定基质细胞、免疫细胞和细胞外基质。此外，头颈部癌细胞之间的相互作用也对头颈部癌的个体化精准治疗起到至关重要的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Oral Pathology & Medicine 医学-病理学

CiteScore

5.90

自引率

6.10%

发文量

121

审稿时长

4-8 weeks

期刊介绍： The aim of the Journal of Oral Pathology & Medicine is to publish manuscripts of high scientific quality representing original clinical, diagnostic or experimental work in oral pathology and oral medicine. Papers advancing the science or practice of these disciplines will be welcomed, especially those which bring new knowledge and observations from the application of techniques within the spheres of light and electron microscopy, tissue and organ culture, immunology, histochemistry and immunocytochemistry, microbiology, genetics and biochemistry.