Arsenic's shadowy influence: A systematic review of its carcinogenic role in gallbladder cancer

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-04-01 DOI:10.1002/jhbp.1428

Anas Elgenidy, Ramez M. Odat, Horiah Amer Al-Ghorbany, Hatim Nasruldin Shahin, Ibrahim S. Abdel-bary, Roaa AbdulTawab AbdulHamid, Amal Dhahab, Moustafa Salem, Youmna A. Negm, Nada Mostafa El Attar, Ahmed Assem Abdelfattah, Mai M. Khaliel, Shehab M. Moawad, Ahmed M. Afifi

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引用次数: 0

Abstract

Introduction

Gallbladder carcinoma (GBC) and cholangiocarcinoma are aggressive forms of cancer developed in the gallbladder and biliary tracts which are related to the liver. This systematic review aimed to highlight the significant association between gallbladder, biliary cancers, and arsenic exposure.

Methods

An extensive search was conducted in Embase, Cochrane, Scopus, PubMed, and Web of Science. We included studies that assessed arsenic levels in gallbladder cancer patients, without restrictions on age, sex, or language. Biological samples, such blood, bile, gallbladder tissue, gallstones, and hair were obtained, and arsenic levels were measured. Also, arsenic water and soil concentrations were collected.

Results

A total of 13 studies were included in our review. These studies included 2234 non-gallbladder carcinoma patients and 22 585 gallbladder carcinoma cases. The participant demographics showed a gender distribution of 862 males and 1845 females, with an age range of 20–75 years. The average body mass index (BMI) was 19.8 kg/m² for nongallbladder carcinoma patients and 20.1 kg/m² for gallbladder carcinoma cases. The selected studies examined arsenic concentrations across various biological samples, including blood, hair, gallstones, and bile. Blood arsenic levels ranged from 0.0002 to 0.3893 μg/g and were significantly associated with increased gallbladder carcinoma risk in several studies. Hair also demonstrated a significant correlation, with arsenic concentrations ranging from 0.0002 to 6.9801 μg/g.

Conclusion

There is a strong link between arsenic exposure and gallbladder cancer or cholangiocarcinoma. Even chronic exposure to low-moderate amounts could lead to gallbladder carcinoma. These findings stress the need for more comprehensive and dedicated studies, to control arsenic water/soil levels and seek other preventive measures for this high mortality disease.

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砷的阴暗影响：关于砷在胆囊癌中致癌作用的系统回顾。

简介胆囊癌（GBC）和胆管癌是发生在胆囊和胆道的侵袭性癌症，与肝脏有关。本系统综述旨在强调胆囊癌、胆道癌与砷暴露之间的重要关联：我们在 Embase、Cochrane、Scopus、PubMed 和 Web of Science 中进行了广泛的搜索。我们纳入了评估胆囊癌患者体内砷水平的研究，对年龄、性别或语言均无限制。我们采集了血液、胆汁、胆囊组织、胆结石和毛发等生物样本，并测量了砷含量。此外，还收集了砷在水和土壤中的浓度：结果：共有 13 项研究被纳入我们的综述。这些研究包括 2234 例非胆囊癌患者和 22 585 例胆囊癌患者。参与者的性别分布为 862 名男性和 1845 名女性，年龄范围为 20-75 岁。非胆囊癌患者的平均体重指数（BMI）为 19.8 kg/m2，胆囊癌患者的平均体重指数（BMI）为 20.1 kg/m2。所选研究检测了各种生物样本中的砷浓度，包括血液、毛发、胆结石和胆汁。在多项研究中，血液砷含量从 0.0002 到 0.3893 μg/g 不等，与胆囊癌风险增加有显著关联。头发中的砷浓度从 0.0002 到 6.9801 微克/克不等，也显示出明显的相关性：结论：砷暴露与胆囊癌或胆管癌之间存在密切联系。即使长期接触中低量的砷也可能导致胆囊癌。这些研究结果表明，有必要进行更全面、更专门的研究，以控制水/土壤中的砷含量，并寻求其他预防措施来治疗这种死亡率很高的疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567