Vincarostine A, a novel anti-malarial trimeric monoterpenoid indole alkaloid from Catharanthus roseus

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL

Journal of Natural Medicines Pub Date : 2024-04-02 DOI:10.1007/s11418-024-01795-1

Yusuke Hirasawa, Yusuke Kakizoe, Takahiro Tougan, Nahoko Uchiyama, Toshihiro Horii, Hiroshi Morita

引用次数: 0

Abstract

A novel trimeric monoterpenoid indole alkaloid, vincarostine A (1) consisting of an aspidosperma-iboga-aspidosperma type skeleton, was isolated from the whole plant of Catharanthus roseus. The structure including absolute stereochemistry was elucidated on the basis of 2D NMR data and CD spectrum. Vincarostine A (1) showed anti-malarial activity.

Graphical abstract

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来自长春花的新型抗疟疾三聚单萜吲哚生物碱 Vincarostine A。

从长春花全株中分离出了一种新型三聚单萜吲哚生物碱--长春花碱 A（1），其骨架为aspidosperma-iboga-aspidosperma型。根据二维核磁共振数据和 CD 光谱阐明了其结构，包括绝对立体化学结构。金合欢碱 A（1）具有抗疟疾活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.