NME1 and DCC variants are associated with susceptibility and tumor characteristics in Mexican patients with colorectal cancer.

IF 2.1 Q3 ONCOLOGY

Journal of the Egyptian National Cancer Institute Pub Date : 2024-04-01 DOI:10.1186/s43046-024-00213-7

Rosa María Márquez-González, Anilú Margarita Saucedo-Sariñana, César de Jesús Tovar-Jacome, Patricio Barros-Núñez, Martha Patricia Gallegos-Arreola, Mario Humberto Orozco-Gutiérrez, Ignacio Mariscal-Ramírez, Tomas Daniel Pineda-Razo, Aldo Antonio Alcaraz-Wong, María Eugenia Marín-Contreras, Mónica Alejandra Rosales-Reynoso

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引用次数: 0

Abstract

Background: Colorectal cancer (CRC) ranks third in cancer incidence globally and is the second leading cause of cancer-related mortality. The nucleoside diphosphate kinase 1 (NME1) and netrin 1 receptor (DCC) genes have been associated with resistance against tumorigenesis and tumor metastasis. This study investigates the potential association between NME1 (rs34214448 G > T and rs2302254 C > T) and DCC (rs2229080 G > C and rs714 A > G) variants and susceptibility to colorectal cancer development.

Methods: Samples from 232 colorectal cancer patients and 232 healthy blood donors underwent analysis. Variants were identified using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. Associations were assessed using odds ratios (OR), and the p values were adjusted with Bonferroni test.

Results: Individuals carrying the G/T and T/T genotypes for the NME1 rs34214448 variant exhibited a higher susceptibility for develop colorectal cancer (OR = 2.68, 95% CI: 1.76-4.09, P = 0.001 and OR = 2.47, 95% CI: 1.37-4.47, P = 0.001, respectively). These genotypes showed significant associations in patients over 50 years (OR = 2.87, 95% CI: 1.81-4.54, P = 0.001 and OR = 2.99, 95% CI: 1.54-5.79, P = 0.001 respectively) and with early Tumor-Nodule-Metastasis (TNM) stage (P = 0.001), and tumor location in the rectum (P = 0.001). Furthermore, the DCC rs2229080 variant revealed that carriers of the G/C genotype had an increased risk for develop colorectal cancer (OR = 2.00, 95% CI: 1.28-3.11, P = 0.002) and were associated with age over 50 years, sex, and advanced TNM stages (P = 0.001).

Conclusions: These findings suggest that the NME1 rs34214448 and DCC rs2229080 variants play a significant role in colorectal cancer development.

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NME1 和 DCC 变异与墨西哥结直肠癌患者的易感性和肿瘤特征有关。

背景：结直肠癌（CRC）在全球癌症发病率中排名第三，是癌症相关死亡的第二大原因。核苷二磷酸激酶 1（NME1）和净蛋白 1 受体（DCC）基因与肿瘤发生和肿瘤转移的抵抗力有关。本研究调查了 NME1（rs34214448 G > T 和 rs2302254 C > T）和 DCC（rs2229080 G > C 和 rs714 A > G）变异与结直肠癌发病易感性之间的潜在关联：对 232 名结直肠癌患者和 232 名健康献血者的样本进行了分析。采用聚合酶链式反应-限制性片段长度多态性（PCR-RFLP）方法鉴定变异。相关性用几率比（OR）进行评估，P值用Bonferroni检验进行调整：结果：NME1 rs34214448变异的G/T和T/T基因型携带者患结直肠癌的易感性较高（OR=2.68，95% CI：1.76-4.09，P=0.001；OR=2.47，95% CI：1.37-4.47，P=0.001）。这些基因型在 50 岁以上的患者中显示出明显的相关性（OR = 2.87，95% CI：1.81-4.54，P = 0.001 和 OR = 2.99，95% CI：1.54-5.79，P = 0.001），并与早期肿瘤-结节-转移（TNM）分期（P = 0.001）和肿瘤位置在直肠（P = 0.001）相关。此外，DCC rs2229080变异显示，G/C基因型携带者罹患结直肠癌的风险增加（OR = 2.00，95% CI：1.28-3.11，P = 0.002），且与50岁以上年龄、性别和TNM分期晚期有关（P = 0.001）：这些研究结果表明，NME1 rs34214448和DCC rs2229080变异在结直肠癌的发展中起着重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Egyptian National Cancer Institute ONCOLOGY-

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

11 weeks

期刊介绍： As the official publication of the National Cancer Institute, Cairo University, the Journal of the Egyptian National Cancer Institute (JENCI) is an open access peer-reviewed journal that publishes on the latest innovations in oncology and thereby, providing academics and clinicians a leading research platform. JENCI welcomes submissions pertaining to all fields of basic, applied and clinical cancer research. Main topics of interest include: local and systemic anticancer therapy (with specific interest on applied cancer research from developing countries); experimental oncology; early cancer detection; randomized trials (including negatives ones); and key emerging fields of personalized medicine, such as molecular pathology, bioinformatics, and biotechnologies.