Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet.

IF 1.3 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Endocrine journal Pub Date : 2024-05-23 Epub Date: 2024-03-29 DOI:10.1507/endocrj.EJ23-0567
Xiaojuan Li, Luming Qiao, Wei Wang, Ying Shi, Lei Yuan, Zhiwei Zhai
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Abstract

Obesity is affecting global health with multiple complications, including cardiac dysfunction. Currently, it is uncertain whether drug therapy should be applied in the early stages of obesity-induced cardiac dysfunction, with weight reduction as the first choice. Sleeve gastrectomy (SG) has been widely used to treat obesity and its complications, showing promising results. However, it remains unclear whether SG can alleviate obesity-induced cardiac dysfunction. A sudden decline in body weight and food intake was observed in both the obese and obese + SG groups, with a higher rate of increase observed in the Obese group. Elevated levels of plasma glucose, serum insulin, and glycated haemoglobin in obese rats were significantly reduced by SG. Markedly increased levels of alanine transaminase, aspartate transaminase, alkaline phosphatase albumin, total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels, elevated values of heart rate, left ventricular end-systolic pressure, left ventricular end-diastolic pressure, systolic pressure, and end diastolic pressure, and decreased value of stroke volume were observed in obese rats, which were sharply reversed by SG. Furthermore, enhanced pathological changes, including inflammatory cell infiltration and loss of cytoplasm striations, enhanced oil red O staining, increased TUNEL-positive cells, upregulated Bax and cleaved-caspase-3, and downregulated Bcl-2, were observed in obese rats, which were notably alleviated by SG. Lastly, the increased levels of relative proteins observed in obese rats were significantly reduced by SG. In conclusion, SG improved cardiac function and glucose-lipid metabolism disorders in obese rats induced by a high-fat and high-sugar diet.

袖带胃切除术可改善高脂高糖饮食诱导的肥胖大鼠的心脏功能和糖脂代谢紊乱。
肥胖症正在影响全球健康,并引发多种并发症,包括心功能障碍。目前,尚不确定是否应在肥胖导致心脏功能障碍的早期阶段采用药物治疗,而应将减轻体重作为首选。袖带胃切除术(SG)已被广泛用于治疗肥胖症及其并发症,并显示出良好的效果。然而,袖带胃切除术能否缓解肥胖引起的心脏功能障碍,目前仍不清楚。在肥胖组和肥胖 + SG 组均观察到体重和食物摄入量突然下降,其中肥胖组的下降率更高。肥胖大鼠血浆葡萄糖、血清胰岛素和糖化血红蛋白水平的升高在 SG 的作用下明显降低。肥胖大鼠的丙氨酸转氨酶、天门冬氨酸转氨酶、碱性磷酸酶白蛋白、总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平明显升高,心率、左室收缩末压、左室舒张末压、收缩压和舒张末压的值升高,每搏量的值下降,这些都被 SG 逆转。此外,肥胖大鼠的病理变化增强,包括炎性细胞浸润和细胞质条纹消失、油红 O 染色增强、TUNEL 阳性细胞增加、Bax 和裂解-天冬酶-3 上调、Bcl-2 下调,而 SG 能显著缓解这些变化。最后,在肥胖大鼠体内观察到的相对蛋白水平升高也因 SG 而明显降低。总之,SG 可改善高脂高糖饮食诱导的肥胖大鼠的心脏功能和糖脂代谢紊乱。
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来源期刊
Endocrine journal
Endocrine journal 医学-内分泌学与代谢
CiteScore
4.30
自引率
5.00%
发文量
224
审稿时长
1.5 months
期刊介绍: Endocrine Journal is an open access, peer-reviewed online journal with a long history. This journal publishes peer-reviewed research articles in multifaceted fields of basic, translational and clinical endocrinology. Endocrine Journal provides a chance to exchange your ideas, concepts and scientific observations in any area of recent endocrinology. Manuscripts may be submitted as Original Articles, Notes, Rapid Communications or Review Articles. We have a rapid reviewing and editorial decision system and pay a special attention to our quick, truly scientific and frequently-citable publication. Please go through the link for author guideline.
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