Nutrition, endocannabinoids, and the use of cannabis: An overview for the nutrition clinician.

IF 2.1 4区 医学 Q3 NUTRITION & DIETETICS
Nutrition in Clinical Practice Pub Date : 2024-08-01 Epub Date: 2024-03-30 DOI:10.1002/ncp.11148
Lindsey Russell, Kayla Condo, Tiffany DeFlorville
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引用次数: 0

Abstract

The endocannabinoid system (ECs) is composed of multiple signaling compounds and receptors within the central and peripheral nervous system along with various organs, including the gut, liver, and skeletal muscle. The ECs has been implicated in metabolism, gut motility, and eating behaviors. The ECs is altered in disease states such as obesity. Recent studies have clarified the role of the gut microbiome and nutrition on the ECs. Exogenous cannabinoid (CB) use, either organic or synthetic, stimulates the ECs through CB1 and CB2 receptors. However, the role of CBs is unclear in regard to nutrition optimization or to treat disease states. This review briefly summarizes the effect of the ECs and exogenous CBs on metabolism and nutrition. With the increased legalization of cannabis, there is a corresponding increased use in the United States. Therefore, nutrition clinicians need to be aware of both the benefits and harm of cannabis use on overall nutrition status, as well as the gaps in knowledge for future research and guideline development.

营养、内源性大麻素和大麻的使用:营养临床医生概述。
内源性大麻素系统(ECs)由中枢和外周神经系统以及肠道、肝脏和骨骼肌等多个器官内的多种信号化合物和受体组成。内源性大麻素系统与新陈代谢、肠道蠕动和饮食行为有关。在肥胖等疾病状态下,ECs 会发生改变。最近的研究阐明了肠道微生物群和营养对 ECs 的作用。有机或合成的外源性大麻素(CB)可通过 CB1 和 CB2 受体刺激肠黏膜。然而,大麻素在优化营养或治疗疾病方面的作用尚不明确。本综述简要总结了ECs和外源性CBs对新陈代谢和营养的影响。随着大麻合法化程度的提高,美国大麻的使用也相应增加。因此,营养临床医生需要了解使用大麻对整体营养状况的益处和害处,以及未来研究和指南制定方面的知识缺口。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.00
自引率
9.70%
发文量
128
审稿时长
3 months
期刊介绍: NCP is a peer-reviewed, interdisciplinary publication that publishes articles about the scientific basis and clinical application of nutrition and nutrition support. NCP contains comprehensive reviews, clinical research, case observations, and other types of papers written by experts in the field of nutrition and health care practitioners involved in the delivery of specialized nutrition support. This journal is a member of the Committee on Publication Ethics (COPE).
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