Sutherlandiosides E−K: Further cycloartane glycosides from Sutherlandia frutescens

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2024-03-29 DOI:10.1016/j.phytol.2024.03.012

Billy T. Tchegnitegni , Mookho S. Lerata , Denzil R. Beukes , Edith M. Antunes

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Abstract

A further chemical investigation of the butanol extract of leaves from the South African medicinal plant Sutherlandia frutescens led to the isolation of eight previously unreported saponins (1−8), together with the known sutherlandiosides A−D. Their structures were established by spectroscopic (1D and 2D NMR) analyses, CD, optical rotation, mass spectrometry, as well as chemical conversions. The isolates were screened for their cytotoxic activity against the MCF-7 human breast cancer cell line, although no significant activity was observed. In addition to the chemophenetic markers for this genus, i.e. the cycloartane glycosides, the present work also reports on the first isolation of an oleanan-type saponin from the Sutherlandia genus, forming an important fingerprint for the chemical composition of the plant.

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Sutherlandiosides E-K: Sutherlandia frutescens 的进一步环木菠萝烷苷

通过对南非药用植物 Sutherlandia frutescens 的丁醇提取物进行进一步的化学研究，分离出了八种以前未报道过的皂甙（1-8），以及已知的苏铁皂甙 A-D。通过光谱（1D 和 2D NMR）分析、CD、旋光、质谱分析以及化学转换，确定了它们的结构。对分离物进行了筛选，以检测其对 MCF-7 人类乳腺癌细胞系的细胞毒活性，但未观察到明显的活性。除了该属的化学遗传标记（即环木菠萝烷苷）外，本研究还首次从萨瑟兰属植物中分离出一种齐墩果烷型皂苷，为该植物的化学成分提供了重要的指纹图谱。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.