Sadaf Jamal Gilani, Syed Sarim Imam, Raisuddin Ali
{"title":"Formulation and evaluation of multicomponent inclusion complex of cyclosporine A","authors":"Sadaf Jamal Gilani, Syed Sarim Imam, Raisuddin Ali","doi":"10.1007/s10847-024-01225-5","DOIUrl":null,"url":null,"abstract":"<div><p>Cyclosporine A (CP) inclusion complex using cyclodextrin (binary) and cyclodextrin with TPGS (ternary) was prepared by the freeze-drying method. The phase solubility study was performed to calculate the solubility parameters. The prepared formulations were evaluated for saturation solubility and drug release studies. The spectroscopy and molecular docking studies were performed to confirm the formation of inclusion complex. The phase solubility results revealed a high stability constant for both binary and ternary samples. A significant enhancement in saturation solubility and dissolution was found in the prepared inclusion complexes. The spectroscopy studies revealed no interaction between the drug and carrier. The molecular docking study displayed the formation of a stable complex with a good docking score. The diffraction pattern showed the conversion of crystalline CP into an amorphous form after the formation of the inclusion complex. The findings were also supported by the saturation solubility study, which showed a significant enhancement in solubility. From the results, it can be concluded that Cyclosporine A inclusion complex using HP βCD with TPGS is an excellent delivery system. Therefore, the prepared delivery systems may be an alternative to the conventional delivery system for enhanced solubility of highly lipophilic drugs.</p></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"104 7-8","pages":"383 - 394"},"PeriodicalIF":2.3000,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10847-024-01225-5","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
引用次数: 0
Abstract
Cyclosporine A (CP) inclusion complex using cyclodextrin (binary) and cyclodextrin with TPGS (ternary) was prepared by the freeze-drying method. The phase solubility study was performed to calculate the solubility parameters. The prepared formulations were evaluated for saturation solubility and drug release studies. The spectroscopy and molecular docking studies were performed to confirm the formation of inclusion complex. The phase solubility results revealed a high stability constant for both binary and ternary samples. A significant enhancement in saturation solubility and dissolution was found in the prepared inclusion complexes. The spectroscopy studies revealed no interaction between the drug and carrier. The molecular docking study displayed the formation of a stable complex with a good docking score. The diffraction pattern showed the conversion of crystalline CP into an amorphous form after the formation of the inclusion complex. The findings were also supported by the saturation solubility study, which showed a significant enhancement in solubility. From the results, it can be concluded that Cyclosporine A inclusion complex using HP βCD with TPGS is an excellent delivery system. Therefore, the prepared delivery systems may be an alternative to the conventional delivery system for enhanced solubility of highly lipophilic drugs.
期刊介绍:
The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites.
The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.