High-resolution structures of amyloid-β and tau aggregates in individuals with Down syndrome

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-03-29 DOI:10.1038/s41594-024-01254-1

引用次数: 0

Abstract

Cryo-electron microscopy of brain tissue from two individuals with Down syndrome showed amyloid-β (Aβ) and tau filaments identical to those found in individuals with sporadic or dominantly inherited Alzheimer disease (AD), but also two types of Aβ40 filaments with distinct structures different from those previously reported in AD and cerebral amyloid angiopathy.

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唐氏综合征患者体内淀粉样蛋白-β和tau聚集体的高分辨率结构

对两名唐氏综合征患者的脑组织进行冷冻电镜检查后发现，淀粉样蛋白-β（Aβ）和tau细丝与散发性或显性遗传性阿尔茨海默病（AD）患者体内发现的淀粉样蛋白-β和tau细丝相同，但也发现了两种类型的Aβ40细丝，其结构与之前报道的AD和脑淀粉样血管病中的Aβ40细丝不同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.