Relating depressive and manic symptomatology to 1H-MRS spectra

Q3 Psychology

Journal of Affective Disorders Reports Pub Date : 2024-03-23 DOI:10.1016/j.jadr.2024.100774

Alexa Choquette , Alecia Dager , Małgorzata Marjańska , Molly Zatony , Godfrey D. Pearlson , David C. Glahn , Emma.E.M. Knowles

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引用次数: 0

Abstract

Background

Alterations in neurochemical levels are potential biomarkers of affective disorders and offer a window into illness etiology. Much of the research done to date limits focus to few metabolites and relies on dichotomous diagnoses. Here, using ¹H magnetic resonance spectroscopy (MRS), we generate profiles of association between depressive and manic symptom rating scales and numerous metabolites.

Methods

MRS data were collected in 30 individuals (7 = major depressive disorder; 5 bipolar disorder and 18 unaffected individuals) in the right anterior cingulate cortex (ACC), insula and hippocampus. All participants were administered mania and depression symptom scales.

Results

Small to medium relationships were observed between total choline (tCho), N-acetylaspartate (NAA), myo-inositol (mIns) and depressive and manic symptoms. Associations between NAA and mania (r = –0.47, p = 8.88×10⁻⁰³) in the hippocampus, and tCho (r = –0.48, p = 8.79×10⁻⁰³) and NAA (r = –0.44, p = 0.01) and mania in the ACC withstood multiple testing correction.

Conclusions

Elevated levels of choline-containing compounds (tCho) and reduced NAA measured in the ACC and hippocampus are associated with mania indexed dimensionally. These metabolites may represent potential in vivo biomarkers for bipolar disorder symptomatology that warrant follow-up.

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将抑郁症状和躁狂症状与 1H-MRS 图谱联系起来

背景神经化学物质水平的变化是情感障碍的潜在生物标志物，也是了解疾病病因的一个窗口。迄今为止所做的大部分研究都将重点局限于少数几种代谢物，并依赖于二分法诊断。在这里，我们使用 1H 磁共振波谱（MRS）生成了抑郁症和躁狂症症状评分量表与多种代谢物之间的关联图谱。方法：我们收集了 30 人（7 人患有重度抑郁症；5 人患有双相情感障碍；18 人未受影响）右侧前扣带回皮层（ACC）、脑岛和海马的 MRS 数据。结果观察到总胆碱（tCho）、N-乙酰天冬氨酸（NAA）、肌醇（mIns）与抑郁症状和躁狂症状之间存在小到中等的关系。在海马中，NAA与躁狂症之间的关系（r = -0.47，p = 8.88×10-03）；在ACC中，tCho（r = -0.48，p = 8.79×10-03）和NAA（r = -0.44，p = 0.01）与躁狂症之间的关系经受住了多重测试校正。这些代谢物可能是双相情感障碍症状的潜在体内生物标志物，值得进行跟踪研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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