Two undescribed compounds from Aspergillus Niger, an endophytic fungus isolated from Camellia flavida.

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-08-01 Epub Date: 2024-03-29 DOI:10.1080/14786419.2024.2334325

Siyuan Ma, Li Ge, Hongyu Lu, Jianhua Yan, Kedi Yang

引用次数: 0

Abstract

A new naphtho-γ-pyrone dimer, asperosperma A, and a new methyl nicotinate derivative, asperosperma B, with 12 known compounds were isolated from the endophytic fungus Aspergillus niger from the stem of Camellia flavida. Their structure was elucidated by NMR, ECD spectrum, and HR-ESI-MS data. Asperosperma A exhibited a highly cytotoxicity against H460 and 4T1 cancer cells with the IC₅₀ values were 0.37 ± 0.06 and 2.04 ± 0.79 μM, respectively. Moreover, it showed a highly sensitive against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and methicillin-resistant S. aureus.

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从茶花中分离出的一种内生真菌--尼日尔曲霉中发现两种未曾描述过的化合物。

从茶花茎中的内生真菌黑曲霉中分离出了一种新的萘-γ-吡喃酮二聚体 Asperosperma A 和一种新的烟酸甲酯衍生物 Asperosperma B，以及 12 种已知化合物。通过核磁共振、ECD 光谱和 HR-ESI-MS 数据阐明了它们的结构。Asosperma A 对 H460 和 4T1 癌细胞具有很强的细胞毒性，IC50 值分别为 0.37 ± 0.06 和 2.04 ± 0.79 μM。此外，它还对金黄色葡萄球菌、大肠杆菌、铜绿假单胞菌和耐甲氧西林金黄色葡萄球菌具有高度敏感性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.