Structural analysis of resistance-nodulation cell division transporters.

IF 8 1区 生物学 Q1 MICROBIOLOGY
Microbiology and Molecular Biology Reviews Pub Date : 2024-06-27 Epub Date: 2024-03-29 DOI:10.1128/mmbr.00198-23
Philip A Klenotic, Edward W Yu
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引用次数: 0

Abstract

SUMMARYInfectious bacteria have both intrinsic and acquired mechanisms to combat harmful biocides that enter the cell. Through adaptive pressures, many of these pathogens have become resistant to many, if not all, of the current antibiotics used today to treat these often deadly infections. One prominent mechanism is the upregulation of efflux systems, especially the resistance-nodulation-cell division class of exporters. These tripartite systems consist of an inner membrane transporter coupled with a periplasmic adaptor protein and an outer membrane channel to efficiently transport a diverse array of substrates from inside the cell to the extracellular space. Detailed mechanistic insight into how these inner membrane transporters recognize and shuttle their substrates can ultimately inform both new antibiotic and efflux pump inhibitor design. This review examines the structural basis of substrate recognition of these pumps and the molecular mechanisms underlying multidrug extrusion, which in turn mediate antimicrobial resistance in bacterial pathogens.

抗性结节细胞分裂转运体的结构分析。
摘要 感染性细菌具有内在和后天机制来对抗进入细胞的有害生物制剂。通过适应性压力,这些病原体中的许多已经对许多(如果不是全部)目前用于治疗这些往往致命的感染的抗生素产生了耐药性。其中一个突出的机制是外排系统的上调,特别是抗性-结节-细胞分裂类外排系统。这些三方系统由内膜转运体、质外适配蛋白和外膜通道组成,能有效地将各种底物从细胞内转运到细胞外。从机理上深入了解这些内膜转运体如何识别和转运底物,最终能为新型抗生素和外排泵抑制剂的设计提供依据。本综述探讨了这些泵底物识别的结构基础和多药挤出的分子机制,这些机制反过来又介导了细菌病原体的抗菌药耐药性。
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来源期刊
CiteScore
18.80
自引率
0.80%
发文量
27
期刊介绍: Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.
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