Phase Separation of Chromatin Structure-related Biomolecules: A Driving Force for Epigenetic Regulations.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Jiao Wang, Yuchen Chen, Zixuan Xiao, Xikai Liu, Chengyu Liu, Kun Huang, Hong Chen
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引用次数: 0

Abstract

Intracellularly, membrane-less organelles are formed by spontaneous fusion and fission of macro-molecules in a process called phase separation, which plays an essential role in cellular activities. In certain disease states, such as cancers and neurodegenerative diseases, aberrant phase separations take place and participate in disease progression. Chromatin structure-related proteins, based on their characteristics and upon external stimuli, phase separate to exert functions like genome assembly, transcription regulation, and signal transduction. Moreover, many chromatin structure-related proteins, such as histones, histone-modifying enzymes, DNA-modifying enzymes, and DNA methylation binding proteins, are involved in epigenetic regulations through phase separation. This review introduces phase separation and how phase separation affects epigenetics with a focus on chromatin structure-related molecules.

染色质结构相关生物大分子的相分离:表观遗传调控的驱动力。
在细胞内,无膜细胞器是由大分子自发融合和分裂形成的,这一过程被称为相分离,在细胞活动中发挥着重要作用。在某些疾病状态下,如癌症和神经退行性疾病,会发生异常的相分离,并参与疾病的进展。染色质结构相关蛋白会根据自身特性和外部刺激进行相分离,从而发挥基因组组装、转录调控和信号转导等功能。此外,许多染色质结构相关蛋白,如组蛋白、组蛋白修饰酶、DNA修饰酶和DNA甲基化结合蛋白等,通过相分离参与表观遗传调控。本综述以染色质结构相关分子为重点,介绍相分离以及相分离如何影响表观遗传学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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