Hypothalamic hamartoma, precocious puberty and gelastic seizures: A special model of “epileptic” developmental disorder

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-03-27 DOI:10.1684/j.1950-6945.2000.tb00347.x

Thierry Deonna, Anne‐Lise Ziegler

引用次数: 0

Abstract

Based on a review of the litterature and a detailed longitudinal single case study of a child with early onset gelastic seizures and hypothalamic hamartoma, the authors review the arguments suggesting that the acquired cognitive and behavioral symptoms seen in the majority of cases of this special epileptic syndrome result from a direct effect of the seizures. The early neurobehavioral profile of the case presented in this paper and that of a previous study is particular and combines features of a pervasive developmental and an attention deficit disorder which are probably closely related to the particular location of the epilepsy and its spread from the hypothalamus.

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下丘脑火腿肠瘤、性早熟和凝胶痉挛：癫痫 "发育障碍的特殊模型

根据对文献的综述以及对一名患有早发胶样癫痫发作和下丘脑火腿肠瘤的儿童进行的详细纵向单个病例研究，作者回顾了一些论点，这些论点表明，在这种特殊癫痫综合征的大多数病例中出现的后天认知和行为症状是由癫痫发作的直接影响造成的。本文介绍的病例和之前的一项研究显示，该病例的早期神经行为特征很特别，结合了广泛性发育障碍和注意力缺陷障碍的特征，这可能与癫痫的特殊位置及其从下丘脑扩散密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.