The Protective Effects of Vanillic Acid and Vanillic Acid-Coated Silver Nanoparticles (AgNPs) in Streptozotocin-Induced Diabetic Rats

IF 3.6 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Research Pub Date : 2024-03-28 DOI:10.1155/2024/4873544

Eman S. Alamri, Haddad A. El Rabey

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引用次数: 0

Abstract

The production of nanoparticles enhances the bioactivity of biological molecules for drug delivery to diseased sites. This study explains how silver nanoparticle (AgNP) coating enhanced the protection effects of vanillic acid in male diabetic rats with streptozotocin- (STZ-) induced diabetes. Twenty-four rats were divided into four groups () for this investigation. The first group (G1) is untreated, whereas diabetes was induced in the other three groups through STZ injection. Diabetic rats that were not getting therapy were included in the second group (G2, STZ-positive), whereas the other diabetic rats were divided into the third group (G3, vanillic acid-treated) and the fourth group (G4, vanillic acid-coated AgNPs treated). The treatment lasted four weeks. In G2, the induction of diabetes significantly (at ) increased in serum glucose, glycated proteins, renal indices, interleukin-6 (IL-6), K+, immunoglobulins, and lipid peroxidation, while decreased Ca++, Na+, and other antioxidants in the kidney tissue homogenate. In addition, pathological altered signs were present in the pancreas and kidneys of diabetic rats. The renal and pancreatic tissues were effectively enhanced by vanillic acid or vanillic acid-coated AgNPs, bringing them very close to their prediabetic conditions. Vanillic acid-coated AgNPs offered a stronger defense against STZ-induced diabetes and lessened the effects of hyperglycemia compared to ordinary vanillic acid. Additionally, using vanillic acid coated with silver nanoparticles greatly increased the antioxidant and antidiabetic activity and reduced inflammation when compared to using vanillic acid alone.

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香草酸和香草酸包银纳米粒子（AgNPs）对链脲佐菌素诱导的糖尿病大鼠的保护作用

纳米粒子的生产增强了生物分子的生物活性，可将药物输送到患病部位。本研究解释了银纳米粒子（AgNP）涂层如何增强香草酸对链脲佐菌素（STZ）诱导的雄性糖尿病大鼠的保护作用。本次研究将 24 只大鼠分为四组（）。第一组（G1）未接受治疗，其他三组通过注射 STZ 诱发糖尿病。未接受治疗的糖尿病大鼠被分为第二组（G2，STZ 阳性），而其他糖尿病大鼠则被分为第三组（G3，香草酸治疗组）和第四组（G4，香草酸包裹 AgNPs 治疗组）。治疗持续四周。在 G2 组中，诱导糖尿病患者的血清葡萄糖、糖化蛋白、肾脏指数、白细胞介素-6（IL-6）、K+、免疫球蛋白和脂质过氧化显著增加（在），而肾组织匀浆中的 Ca++、Na+和其他抗氧化剂减少。此外，糖尿病大鼠的胰腺和肾脏也出现了病理改变。香草酸或香草酸包衣的 AgNPs 能有效增强肾脏和胰腺组织的功能，使其非常接近糖尿病前的状态。与普通香草酸相比，包覆香草酸的 AgNPs 能更有效地抵御 STZ 诱导的糖尿病，并减轻高血糖的影响。此外，与单独使用香草酸相比，使用涂有银纳米粒子的香草酸大大提高了抗氧化和抗糖尿病活性，并减少了炎症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Research ENDOCRINOLOGY & METABOLISM-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

8.40

自引率

2.30%

发文量

152

审稿时长

14 weeks

期刊介绍： Journal of Diabetes Research is a peer-reviewed, Open Access journal that publishes research articles, review articles, and clinical studies related to type 1 and type 2 diabetes. The journal welcomes submissions focusing on the epidemiology, etiology, pathogenesis, management, and prevention of diabetes, as well as associated complications, such as diabetic retinopathy, neuropathy and nephropathy.